Malignant granular cell tumors: Combining cytological and pathological findings for a definitive diagnosis
Malignant granular cell tumors: Combining cytological and pathological findings for a definitive diagnosis
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DOI：
10.1002/dc.24970
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发表时间：
2022-04-26
影响因子：
1.3
通讯作者：
Terasaki，Yasuhiro
中科院分区：
文献类型：
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作者：
Enomoto，Atsumi;Terasaki，Mika;Terasaki，Yasuhiro
恶性颗粒细胞瘤(GCT)占所有GCT的不到2%，主要发生在大腿或躯干深部软组织。恶性GCTS是一种高度侵袭性的肿瘤，具有很高的复发和转移率。在这篇简短的报告中，我们描述了一例罕见的恶性骨巨细胞瘤，患者为，男，男，女，左腹股沟腹股沟有一个14 × 20 cm的肿块，罕见。细针抽吸细胞学表现为异型上皮样颗粒细胞，背景有颗粒物，难以与大汗腺癌或黑色素瘤相鉴别。免疫组织化学结果显示，肿瘤细胞S-100和溶酶体标志物CD68阳性，提示为巨细胞瘤。然而，粉碎伪影的存在使识别细胞异型性变得具有挑战性，这是恶性肿瘤的一个特征。综合考虑，FNA和针吸活检结果提示为恶性GCT。术前诊断恶性GCT的重要性是众所周知的，但很少有报告描述其细胞学结果。在我们的简短报告中，我们表明，结合细胞学FNA和活检结果与IHC结果相结合，可以实现恶性GCT的准确诊断。
Malignant granular cell tumors (GCTs) account for less than 2% of all GCTs and mainly occur in the deep soft tissue of the thigh or trunk. Malignant GCTs are highly aggressive tumors with high rates of recurrence and metastasis. In this brief report, we describe a rare case of malignant GCT in a 64‐year‐old Japanese man who presented with a 14 × 20 cm mass in the left inguinal region. The cytologic findings of fine‐needle aspiration (FNA) revealed atypical epithelial‐like granular cells with granular substance in the background, which was difficult to differentiate from apocrine carcinoma or melanoma. The immunohistochemistry (IHC) findings of the needle biopsy revealed that the tumor cells were positive for S‐100 and lysosomal marker CD68 which was suggestive of a GCT. However, the presence of crush artifacts made it challenging to identify cellular atypia, which is a characteristic of malignant tumor. Taken together, the FNA and needle biopsy results were suggestive of malignant GCT. The importance of preoperative diagnosis of malignant GCT is well known, but few reports have described its cytological findings. In our brief report, we show that combining cytological FNA and biopsy findings with IHC findings achieves an accurate diagnosis of malignant GCT.