We need to talk about lung cancer's cholesterol-hoarding problem.
We need to talk about lung cancer's cholesterol-hoarding problem.
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我们需要谈谈肺癌的胆固醇囤积问题。
DOI：
10.1016/j.stem.2023.05.006
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发表时间：
2023
期刊：
影响因子：
23.9
通讯作者：
Fessler,MichaelB
中科院分区：
文献类型：
--
作者：
Fessler,MichaelB
消化细胞需要过量的胆固醇来支持快速的膜生物合成。使用非小细胞肺癌的突变KRAS小鼠模型，Guilbaud et al.表明肺癌通过局部和远端重编程脂质运输来积累胆固醇，并且胆固醇去除干预可能有望作为治疗策略。
Proliferative cells require excess cholesterol to support rapid membrane biogenesis. Using a mutant KRAS mouse model of non-small cell lung cancer, Guilbaud et al. show that lung cancers accumulate cholesterol by locally and distally reprogramming lipid trafficking and that cholesterol-removing interventions may hold promise as a therapeutic strategy.