Early development of broadly neutralizing antibodies in HIV-1-infected infants.
Early development of broadly neutralizing antibodies in HIV-1-infected infants.
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作者：
由于HIV-1广泛的遗传和抗原多样性，激发针对HIV-1的保护性中和抗体（NAb）是令人生畏的。此外，即使在持续感染期间，广泛和有效的反应也是罕见的，只有一部分成年人产生了广泛中和抗体（bNAb），可以识别来自不同HIV-1进化枝的变体。目前尚不清楚bNAb是否也会出现在HIV-1感染的婴儿中，他们通常比成年人更快地发展为疾病，可能部分原因是免疫系统不成熟。在这里，我们表明bNAb在婴儿中的发育至少与成人一样普遍。在20/28例感染婴儿中检测到交叉进化枝NAb应答，在某些情况下，在感染后1年内。在具有最高四分位数应答的婴儿中，在感染后20个月检测到来自多个进化枝的第2-3层变体的中和。这些发现表明，即使在生命早期，也有足够的B细胞功能来安装针对HIV-1的bNAb。此外，婴儿中bNAb的相对早期出现可能为理解导致bNAb的B细胞成熟途径提供了独特的背景。
Eliciting protective neutralizing antibodies (NAbs) against HIV-1 is daunting because of the extensive genetic and antigenic diversity of HIV-1. Moreover, broad and potent responses are uncommon even during persistent infection, with only a subset of adults developing broadly neutralizing antibodies (bNAbs) that recognize variants from different HIV-1 clades. It is not known whether bNAbs can also arise in HIV-1-infected infants, who typically progress to disease faster than adults, presumably in part due to an immature immune system. Here, we show that bNAbs develop at least as commonly in infants as in adults. Cross-clade NAb responses were detected in 20/28 infected infants, in some cases, within 1 year of infection. Among infants with the top quartile of responses, neutralization of Tier 2–3 variants from multiple clades was detected at 20 months post-infection. These findings suggest that, even in early life, there is sufficient B-cell functionality to mount bNAbs against HIV-1. Additionally, the relatively early appearance of bNAbs in infants may provide a unique setting for understanding the pathways of B-cell maturation leading to bNAbs.
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影响因子：
64.8
作者：
Huang J;Ofek G;Laub L;Louder MK;Doria-Rose NA;Longo NS;Imamichi H;Bailer RT;Chakrabarti B;Sharma SK;Alam SM;Wang T;Yang Y;Zhang B;Migueles SA;Wyatt R;Haynes BF;Kwong PD;Mascola JR;Connors M
通讯作者：
Connors M
影响因子：
6.7
作者：
Cortez V;Odem-Davis K;McClelland RS;Jaoko W;Overbaugh J
通讯作者：
Overbaugh J
影响因子：
6.7
作者：
Sanders RW;Derking R;Cupo A;Julien JP;Yasmeen A;de Val N;Kim HJ;Blattner C;de la Peña AT;Korzun J;Golabek M;de Los Reyes K;Ketas TJ;van Gils MJ;King CR;Wilson IA;Ward AB;Klasse PJ;Moore JP
通讯作者：
Moore JP
DOI：
10.1097/qad.0000000000000106
发表时间：
2014-01-14
期刊：
AIDS (London, England)
影响因子：
--
作者：
Hraber P;Seaman MS;Bailer RT;Mascola JR;Montefiori DC;Korber BT
通讯作者：
Korber BT
影响因子：
82.9
作者：
通讯作者：
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