Identification of loci associated with schizophrenia by genome-wide association and follow-up
Identification of loci associated with schizophrenia by genome-wide association and follow-up
复制标题
DOI：
10.1038/ng.201
复制
发表时间：
2008-09-01
期刊：
影响因子：
30.8
通讯作者：
Owen, Michael J.
中科院分区：
文献类型：
--
作者：
O'Donovan, Michael C.;Craddock, Nicholas;Owen, Michael J.
我们进行了一项精神分裂症全基因组关联研究（479例，2，937例对照），并在多达16，726名额外受试者中测试了P < 10（-5）的位点。在12个随访的位点中，3个位点具有强的独立支持（P < 5 × 10（-4）），总体复制模式不太可能偶然发生（P < 9 × 10（-8））。荟萃分析为ZNF 804 A相关性提供了最强有力的证据（P = 1.61 x 10（-7）），当受影响的表型包括双相情感障碍时，这一点得到了加强（P = 9.96 x 10（-9））。
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P < 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).