Safer endoscopic gastric mucosal resection: Preoperative proton pump inhibitor administration
Safer endoscopic gastric mucosal resection: Preoperative proton pump inhibitor administration
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DOI：
10.1111/j.1440-1746.2006.04467.x
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发表时间：
2006-11
影响因子：
4.1
通讯作者：
Yoshiyuki Watanabe;N. Kato;T. Maehata;M. Okamoto;T. Tsuda;Santa Hattori;Shunichi Yamauchi;Kazuhiko Fujita;S. Baba;S. Nakaya;Hiroyuki Inaba;S. Kitajima;Michihiro T. Suzuki;H. Niwa;F. Itoh
中科院分区：
文献类型：
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作者：
Yoshiyuki Watanabe;N. Kato;T. Maehata;M. Okamoto;T. Tsuda;Santa Hattori;Shunichi Yamauchi;Kazuhiko Fujita;S. Baba;S. Nakaya;Hiroyuki Inaba;S. Kitajima;Michihiro T. Suzuki;H. Niwa;F. Itoh
背景和目的：控制出血是提高内镜黏膜切除术（EMR）安全性的关键，而胃内酸度对止血和凝血有很大影响。质子泵抑制剂（PPI）是有效的胃酸抑制剂;然而，PPI需要连续口服给药数天，因此如果PPI仅在EMR后立即给药，则初始效果可能不足。本研究的目的是确定EMR前术前给予PPI是否可以提高胃内酸度，促进更好地控制术中出血（完全凝血和止血），预防术后出血，并促进人工溃疡愈合。
Background and Aim: Control of bleeding is crucial in improving the safety of endoscopic mucosal resection (EMR), and intragastric acidity has a great impact on hemostasis and blood coagulation. Proton pump inhibitors (PPI) are potent suppressors of gastric acid; however, PPI need to be continuously administered orally for several days, and thus initial effects may be insufficient if PPI is only administered immediately after EMR. The aim of this study was to determine whether preoperative administration of PPI prior to EMR can elevate intragastric acidity, facilitate better control of intraoperative bleeding (complete coagulation and hemostasis), prevent postoperative bleeding, and facilitate healing of artificial ulcers.