Very low high-density lipoproteins without coronary atherosclerosis.
Very low high-density lipoproteins without coronary atherosclerosis.
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高密度脂蛋白极低，无冠状动脉粥样硬化。
DOI：
10.1016/0140-6736(93)92933-k
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
BrewerJr,HB
中科院分区：
文献类型：
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作者：
Rader,DJ;Ikewaki,K;Duverger,N;Feuerstein,I;Zech,L;Connor,W;BrewerJr,HB
流行病学研究已经确定，血浆高密度脂蛋白（HDL）浓度与过早动脉粥样硬化呈负相关，但这种关系的生理基础仍然未知。我们调查了5名血浆HDL极低的先证者。没有人具有已知低高密度脂蛋白遗传性疾病的典型临床或生化发现，也没有通过敏感诊断方法获得过早冠状动脉粥样硬化的证据。所有5个先证者和其中1个先证者的儿子都有HDL载脂蛋白A-I和A-II的快速催化。这些结果表明，并不是所有低HDL的人都必然有早发冠心病的风险，在决定对其进行管理之前，需要进一步调查。
Epidemiological studies have established that concentrations of plasma high-density lipoproteins (HDL) are inversely associated with premature atherosclerosis, but the physiological basis of this relationship remains unknown. We investigated 5 probands with very low plasma HDL. None had clinical or biochemical findings typical of the known genetic disorders with low HDL nor had evidence of premature coronary atherosclerosis by sensitive diagnostic methods. All 5 probands and the son of 1 of them had rapid catabolism of the HDL apolipoproteins A-I and A-II. These results indicate that not all people with low HDL are necessarily at risk of premature coronary heart disease and that further investigation is required before decisions can be made about their management.