An approach to 6-trifluoromethyl-phenanthridines through visible-light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides
An approach to 6-trifluoromethyl-phenanthridines through visible-light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides
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DOI：
10.1039/c4ra02384f
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发表时间：
2014-04
期刊：
影响因子：
3.9
通讯作者：
W. Fu;Mei Zhu;Fen Xu;Yuqin Fu;Chen Xu;Dapeng Zou
中科院分区：
文献类型：
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作者：
W. Fu;Mei Zhu;Fen Xu;Yuqin Fu;Chen Xu;Dapeng Zou
在可见光催化下，三氟乙酰亚胺酰氯分子内环化反应合成了6-三氟甲基菲啶衍生物。该反应涉及从C（sp2）-Cl键生成自由基中间体和均裂自由基芳族取代（HAS）过程。
A mild and efficient visible light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides is developed for the synthesis of 6-(trifluoromethyl)phenanthridine derivatives. The reaction involves the generation of radical intermediates from C(sp2)–Cl bonds and a homolytic radical aromatic substitution (HAS) process.