Lymphatic invasion is a significant indicator of poor patient prognosis in lung squamous cell carcinoma.
Lymphatic invasion is a significant indicator of poor patient prognosis in lung squamous cell carcinoma.
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DOI：
10.3892/mmr.2017.6256
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发表时间：
2017-04
影响因子：
3.4
通讯作者：
Iwazaki M
中科院分区：
文献类型：
--
作者：
Masuda R;Kijima H;Nito M;Wada A;Matsuzaki T;Ikoma Y;Nakazato K;Masuda D;Tanaka M;Kobayashi H;Inokuchi S;Iwazaki M
病理分期是肺癌患者最重要的预后因素，根据肿瘤淋巴结转移分类系统来确定病理分期。本研究旨在探讨103例肺鳞状细胞癌（SqCC）手术切除后淋巴浸润的临床病理意义。根据淋巴浸润程度将患者分为两组：无或轻度淋巴浸润组（ly0-1）和中度或重度淋巴浸润组（ly2-3）。Ly2-3与肿瘤大小（P=0.028）、淋巴结转移（P<0.001）、静脉浸润（P=0.001）和组织学分化（P=0.047）相关。Kaplan-Meier法和log-rank检验的统计分析显示，ly2-3患者的总生存期明显低于ly0-1患者（P<0.001）。多变量分析确定ly2-3是死亡率的独立预测因子（风险比2.580；95%可信区间1.376-4.839）。总之，中度或重度淋巴浸润（ly2-3）提示高恶性潜能，可能被认为是肺部SqCC患者预后不良的独立预测因子。
Pathological stage is the most important prognostic factor in patients with lung cancer, and is defined according to the tumor node metastasis classification system. The present study aimed to investigate the clinicopathological significance of lymphatic invasion in 103 patients who underwent surgical resection of lung squamous cell carcinoma (SqCC). The patients were divided into two groups, according to the degree of lymphatic invasion: Those with no or mild lymphatic invasion (ly0-1) and those with moderate or severe lymphatic invasion (ly2-3). Ly2-3 was associated with tumor size (P=0.028), lymph node metastasis (P<0.001), venous invasion (P=0.001) and histological differentiation (P=0.047). Statistical analysis using the Kaplan-Meier method and the log-rank test indicated that overall survival was significantly reduced in patients with ly2-3 compared with those with ly0-1 (P<0.001). Multivariate analysis identified ly2-3 as an independent predictor of mortality (hazard ratio, 2.580; 95% confidence interval, 1.376–4.839). In conclusion, moderate or severe lymphatic invasion (ly2-3) indicated a high malignant potential and may be considered an independent predictor of poor prognosis in patients with SqCC of the lung.