Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde
Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde
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DOI：
10.1111/ced.12950
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发表时间：
2017-01-01
影响因子：
4.1
通讯作者：
Chen, H. -D.
中科院分区：
文献类型：
--
作者：
Shi, M. -H.;Wu, Y.;Chen, H. -D.
背景关于白癜风与超氧化物歧化酶（SOD）或丙二醛（MDA）水平之间的相关性，有相互矛盾的报道。瞄准目的探讨白癜风与SOD、MDA的关系。根据我们的资格标准检索相关的已发表文章。进行荟萃分析，以合并标准化均数差（SMD）的估计值和95% CI。活动期和稳定期白癜风患者血清SOD水平均高于正常对照组（稳定：SMD = 1.61，95% CI 0.66-2.56，P = 0.001;活性：SMD = 2.56，95% CI 1.13-3.99，P < 0.001）和MDA（稳定期：SMD = 2.70，95%CI 1.81-3.59，P < 0.001;活动期：SMD = 3.50，95%CI 2.29-4.71，P < 0.001）。这项荟萃分析显示白癜风与高水平的SOD和MDA之间存在显著相关性。
Background. There are conflicting reports on the correlation between vitiligo and the levels of either superoxide dismutase (SOD) or malondialdehyde (MDA). Aim. To clarify the association between vitiligo and SOD or MDA.Methods. Relevant published articles were searched according to our eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% CI.Results. Patients with either the active or stable vitiligo had higher levels of both SOD (stable: SMD = 1.61, 95% CI 0.66-2.56, P = 0.001; active: SMD = 2.56, 95% CI 1.13-3.99, P < 0.001) and MDA (stable: SMD = 2.70, 95% CI 1.81-3.59, P < 0.001; active: SMD = 3.50, 95% CI 2.29-4.71, P < 0.001), compared with healthy controls.Conclusions. This meta-analysis showed a significant association between vitiligo and high levels of both SOD and MDA.