Effect of romifidine on gastrointestinal motility, assessed by transrectal ultrasonography
Effect of romifidine on gastrointestinal motility, assessed by transrectal ultrasonography
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DOI：
10.2746/042516401776563436
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发表时间：
2001-11-01
影响因子：
2.2
通讯作者：
England, GCW
中科院分区：
文献类型：
--
作者：
Freeman, SL;England, GCW
建立经直肠超声检查技术，研究罗米非定80和120 mg/kgbwt对马肠动力的影响。在6匹马中，采用双盲交叉研究设计，评估了注射罗米非丁和生理盐水对照后的小肠、盲肠和左腹结肠的运动能力。分别于给药后15、30、60、120、180、240min进行测量。在4h的研究期间，对照组的运动性略有不明显的下降。两种剂量的罗米非定均导致胃肠动力显著下降，并与收缩减少(非推进性)有关。经直肠超声被证明适合于监测马肠道运动的类型和频率的变化。
A technique of transrectal ultrasonography was developed to investigate the effects of romifidine 80 and 120 mug/kg bwt on intestinal motility in the horse. Motility of the small intestine, caecum and left ventral colon were assessed following injection of romifidine and a saline control, using a blinded, cross-over study design in 6 horses. Measurements were taken at 15, 30, 60, 120, 180 and 240 min after drug administration. There was a slight nonsignificant decrease in motility in the control group over the 4 h study period. Both doses of romifidine produced a marked decrease in gastrointestinal motility and were associated with the presence of reduced (nonpropulsive) contractions. Transrectal ultrasonography proved suitable for monitoring changes in the type and frequency of intestinal motility in the horse.