Menthol protects dopaminergic neurons against inflammation-mediated damage in lipopolysaccharide (LPS)-Evoked model of Parkinson's disease
Menthol protects dopaminergic neurons against inflammation-mediated damage in lipopolysaccharide (LPS)-Evoked model of Parkinson's disease
复制标题
薄荷醇可保护多巴胺能神经元免受脂多糖 (LPS) 诱发的帕金森病模型中炎症介导的损伤。
DOI：
10.1016/j.intimp.2020.106679
复制
发表时间：
2020-08-01
影响因子：
5.6
通讯作者：
Gao, Fei
中科院分区：
文献类型：
--
作者：
Du, Jian;Liu, Dianfeng;Gao, Fei
In neurodegenerative diseases, neuronal damage caused by neuroinflammation is very important. Many studies have suggested that the activation of microglia is critical for the neuroinflammatory process. Therefore, inhibiting neuroinflammation is considered to be a hopeful target for curing neurodegenerative diseases. In this study, we aimed to explore whether menthol can protect the dopaminergic neurons by exerting anti-inflammatory effects in vivo or in vitro. The results showed that menthol had an inhibitory effect on impaired dopaminergic neurons and LPS-induced microglial activation. Further, menthol can inhibit the expression of related pro-inflammatory enzymes and pro-inflammatory factors. Both in vitro and in vivo mechanistic studies showed that menthol inhibited the neuroinflammatory response through the MAPK, NF-kappa B and AKT signaling pathways.
