Expression of programmed death‐1 (CD279) in primary cutaneous B‐cell lymphomas with correlation to lymphoma entities and biological behaviour
Expression of programmed death‐1 (CD279) in primary cutaneous B‐cell lymphomas with correlation to lymphoma entities and biological behaviour
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原发性皮肤 B 细胞淋巴瘤中程序性死亡 1 (CD279) 的表达与淋巴瘤实体和生物学行为的相关性
DOI：
10.1111/bjd.12579
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发表时间：
2013
影响因子：
10.3
通讯作者：
W. Kempf
中科院分区：
文献类型：
--
作者：
C. Mitteldorf;M. Bieri;N. Wey;K. Kerl;J. Kamarachev;M. Pfaltz;H. Kutzner;G. Roncador;D. Tomasini;W. Kempf
程序性死亡-1 (PD-1/CD279) 是一种在活化 T 细胞和 T 淋巴细胞亚群（包括滤泡辅助 T 细胞 (TFH)）中表达的细胞表面蛋白。 PD-1与其配体之间的相互作用在免疫反应和逃避恶性肿瘤中发挥作用。在淋巴结滤泡性淋巴瘤中，瘤内 PD-1 阳性淋巴细胞的数量与总生存期相关。
Programmed death‐1 (PD‐1/CD279) is a cell‐surface protein expressed in activated T cells and a subset of T lymphocytes including follicular helper T cells (TFH). The interaction between PD‐1 and its ligands plays a role in immune response and evasion of malignancies. In nodal follicular lymphoma, the number of intratumoral PD‐1‐positive lymphocytes is associated with overall survival.