Obesity may impair lactogenesis II
Obesity may impair lactogenesis II
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DOI：
10.1093/jn/131.11.3009s
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发表时间：
2001-11-01
影响因子：
4.2
通讯作者：
Kjolhede, CL
中科院分区：
文献类型：
--
作者：
Rasmussen, KM;Hilson, JA;Kjolhede, CL
来自牲畜物种和实验动物模型的数据表明，身体过度肥胖可能会损害乳汁生成。例如，人们早就知道，过度喂养的奶牛有患肥牛综合症的风险，这种疾病的特征是产后早期哺乳失败。肥胖大鼠通常会在产后早期因初乳失败而遗失幼崽。来自不同人群的研究表明，怀孕前的高体重指数(BMI)与哺乳时间之间存在负相关。我们实验室的研究结果表明，在曾经尝试母乳喂养婴儿的女性中，怀孕前高BMI也与未能成功开始母乳喂养有关。在最近的一项研究中，我们发现孕前高BMI与较晚的第二次产乳有关，这是通过产次而不是母乳喂养行为来调节的。与妇女母乳喂养意向和计划的母乳喂养持续时间有关的心理社会因素并没有改变这种联系。综上所述，在动物和妇女身上的这些发现强烈表明，围产期的母体肥胖是乳汁生成延迟的原因之一。
Data from livestock species and experimental animal models suggest that excess body fatness may impair lactogenesis. For example, it has long been known that overfed dairy cows are at risk of fat cow syndrome, a condition characterized by lactation failure in the early postpartum period. Obese rats often lose their litters in the early postpartum period to primary lactation failure. A negative association between high body mass index (BMI) before conception and the duration of lactation has been documented in studies from diverse human populations. Findings from our laboratory establish that among women who ever attempted to breastfeed their infants, high BMI before conception was also associated with failure to initiate breastfeeding successfully. In a more recent study, we found that high prepregnant BMI was specifically associated with later onset of lactogenesis II. This was mediated by parity but not by breastfeeding behavior. Psychosocial factors related to a woman's intention to breastfeed and her planned duration of breastfeeding did not modify this association. Taken together, these findings in animals and women strongly suggest that maternal obesity in the perinatal period is a cause of delayed lactogenesis.