Family-based association study between monoamine oxidase A (MAOA) gene promoter VNTR polymorphism and Tourette's syndrome in Chinese Han population
Family-based association study between monoamine oxidase A (MAOA) gene promoter VNTR polymorphism and Tourette's syndrome in Chinese Han population
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中国汉族人群单胺氧化酶A（MAOA）基因启动子VNTR多态性与抽动秽语综合征的家系关联研究
DOI：
10.1080/13554794.2013.873061
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发表时间：
2015
期刊：
影响因子：
0.8
通讯作者：
Ma Xu
中科院分区：
文献类型：
--
作者：
Liu Shiguo;Wang Xueqin;Xu Longqiang;Zheng Lanlan;Ge Yinlin;Ma Xu
为探讨中国汉族人群中单胺氧化酶A可变数目串联重复序列(MAOA-pVNTR)与多发性抽动症(TS)易感性的关系，采用传递不平衡检验(TDT)设计，探讨了中国汉族人群中141例TS患者及其父母的MAOA-pVNTR的遗传贡献。结果显示，MAOA基因启动子VntR多态与中国汉族人群TS无显著关联(Tdt=1.515，Df=11.0，p>；0.05)。阴性结果可能主要是由于样本量较小，但我们不否认编码5-羟色胺或单胺能结构的基因在TS的病因中的作用。
To clarify the association of monoamine oxidase A– variable number of tandem repeat (MAOA-pVNTR) with susceptibility to Tourette’s syndrome (TS) in Chinese Han population we discuss the genetic contribution of MAOA–VNTR in 141 TS patients including all their parents in Chinese Han population using transmission disequilibrium test (TDT) design. Our results revealed that no significant association was found in the MAOA gene promoter VNTR polymorphism and TS in Chinese Han population (TDT = 1.515, df = 1,p> 0.05). The negative result may be mainly due to the small sample size, but we don’t deny the role of gene coding serotonergic or monoaminergic structures in the etiology of TS.