Association between commensal bacteria and opportunistic pathogens in the dental plaque of elderly individuals
Association between commensal bacteria and opportunistic pathogens in the dental plaque of elderly individuals
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DOI：
10.1111/j.1469-0691.2006.01497.x
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发表时间：
2006-08-01
影响因子：
14.2
通讯作者：
Tanzawa, H.
中科院分区：
文献类型：
--
作者：
Tada, A.;Senpuku, H.;Tanzawa, H.
老年人口腔的机会性感染可能会增加全身疾病的发生率。本研究的目的是调查依赖老年人(住院患者)和独立老年人(社区居民)口腔菌群的差异。在考虑了多个变量后，住院患者对阿尔法链球菌(p<；0.001)和奈瑟氏菌(p 0.004)的检测率明显低于社区居民，而对铜绿假单胞菌(p 0.024)、耐甲氧西林金黄色葡萄球菌(Mrsa)(p 0.011)和放线菌的检测率较高。(P<0.005)。在住院患者中，对高度护理的需求与α-链球菌的检测呈负相关，但与铜绿假单胞菌(p 0.018)或耐甲氧西林金黄色葡萄球菌(p 0.004)的检测显著相关。与不需要管饲的住院患者相比，管饲住院患者的甲型链球菌的检出率显著降低(p 0.041)，而铜绿假单胞菌的检出率更高(p 0.004)。有抗生素使用史的住院患者与无抗生素使用史的患者相比，甲型链球菌的检测率显著降低(p 0.049)，而耐甲氧西林金黄色葡萄球菌的检测率更高(p 0.007)。在控制了年龄和性别后，无α-链球菌的住院患者的铜绿假单胞菌或耐甲氧西林金黄色葡萄球菌的检出率高于有α-链球菌的住院患者(铜绿假单胞菌，p 0.006；耐甲氧西林金黄色葡萄球菌，p 0.001)。总体而言，α-链球菌的检测与口腔中铜绿假单胞菌和MRSA的检测呈负相关，很可能是病原菌感染的指标。
Opportunistic infections in the oral cavity of the elderly may increase the incidence of systemic disease. The objective of this study was to investigate the differences in the oral bacterial flora between dependent elderly (inpatients) and independent elderly (community-dwelling residents). After multiple variables were taken into account, inpatients had significantly lower detection rates than community-dwelling residents for alpha-streptococci (p < 0.001) and Neisseria (p 0.004), and higher detection rates for Pseudomonas aeruginosa (p 0.024), methicillin-resistant Staphylococcus aureus (MRSA) (p 0.011) and Actinomyces spp. (p 0.005). Among inpatients, the requirement for a high degree of care was related negatively to detection of alpha-streptococci, but was related significantly to detection of P. aeruginosa (p 0.018) or MRSA (p 0.004). Tube-fed inpatients had a significantly lower detection rate for alpha-streptococci (p 0.041) and a higher detection rate for P. aeruginosa (p 0.004) than those who did not require tube feeding. Inpatients with a history of antibiotic use had a significantly lower detection rate for alpha-streptococci (p 0.049) and a higher detection rate for MRSA (p 0.007) than those without a history of antibiotic use. The detection rates for P. aeruginosa or MRSA in inpatients without alpha-streptococci were higher than in inpatients with alpha-streptococci after controlling for age and gender (P. aeruginosa, p 0.006; MRSA, p 0.001). Overall, detection of alpha-streptococci had an inverse correlation with the detection of P. aeruginosa and MRSA in the oral cavity and is likely to be an indicator of pathogenic bacterial infection.