THE METABOLISM IN VIVO OF GLYCINE AND SERINE IN EIGHT AREAS OF THE RAT CENTRAL NERVOUS SYSTEM 1
THE METABOLISM IN VIVO OF GLYCINE AND SERINE IN EIGHT AREAS OF THE RAT CENTRAL NERVOUS SYSTEM 1
复制标题
大鼠中枢神经系统8个区域甘氨酸和丝氨酸的体内代谢1
DOI：
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发表时间：
1970
影响因子：
4.7
通讯作者：
M. H. Aprison
中科院分区：
文献类型：
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作者：
R. Shank;M. H. Aprison
摘要-研究结果旨在估计甘氨酸在大鼠中枢神经系统离散区域的各种可能来源的衍生率。这些结果表明，甘氨酸主要是通过从头合成获得的，可能是通过从葡萄糖到丝氨酸再到甘氨酸的既定途径。甘氨酸在小脑和端脑中的含量低至约0‐6 μmol/g，在脊髓灰质中的含量高至5.5 μmol/g；然而，根据对丝氨酸合成速率的估计，在研究的各个区域中，甘氨酸的含量与其合成速率之间似乎没有相关性。甘氨酸从血液进入中枢神经系统的通量（0.03 ~ 0.15 μmol/g/h，取决于中枢神经系统的结构）比丝氨酸慢（0.15 ~ 0.23 μmol/g/h），两种氨基酸进入中枢神经系统各区域的速度与其各自的组织含量无关。这些数据已经讨论了关于甘氨酸在脊髓和脑干中假定的递质功能。
Abstract— Results of studies designed to estimate the rates at which glycine is derived from various possible sources in discrete areas of the rat CNS are reported. These results suggest that glycine is derived predominantly by de novo synthesis, presumably via the established pathways leading from glucose through serine to glycine. The content of glycine ranged from a low of approximately 0‐6 μmol/g in the cerebellum and telencephalon to a high of 5·5 μmol/g in the spinal cord grey matter; however, based on its estimated rate of synthesis from serine, there appeared to be no correlation between the content of glycine and its rate of synthesis in the various areas studied. The flux of glycine from blood into the CNS was slower (0·03‐0·15 μmol/g/h depending on the CNS structure) than that of serine (0·15‐0·23 μmol/g/h) and both amino acids entered various CNS areas at rates unrelated to their respective tissue contents. These data have been discussed with regard to the putative transmitter function of glycine in the spinal cord and brainstem.