Plasma kallikrein: the bradykinin-producing enzyme
Plasma kallikrein: the bradykinin-producing enzyme
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DOI：
10.1160/th13-03-0258
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发表时间：
2013-09-01
影响因子：
6.7
通讯作者：
Renne, Thomas
中科院分区：
文献类型：
--
作者：
Bjorkqvist, Jenny;Jamsa, Anne;Renne, Thomas
血浆前激肽释放酶是胰酶样丝氨酸蛋白酶血浆激肽释放酶(PK)的肝脏前体，在与高分子激肽原结合的血浆中循环。酶原被激活因子XII转化为PK。PK在心血管系统中驱动多种蛋白水解级联反应，如凝血的内在途径、激肽释放酶-激动素系统、纤溶系统、肾素-血管紧张素系统和替代补体途径。在这里，我们回顾了PK的生物化学和细胞生物学，并重点介绍了最近的体内研究，这些研究已经确定了PK在促凝剂和促炎性疾病状态中的重要功能。靶向PK提供了以前未被认识到的干预多种疾病的血栓形成和血管炎症的新策略。
Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The zymogen is converted to PK by activated factor XII. PK drives multiple proteolytic reaction cascades in the cardiovascular system such as the intrinsic pathway of coagulation, the kallikrein-kinin system, the fibrinolytic system, the renin-angiotensin system and the alternative complement pathway. Here, we review the biochemistry and cell biology of PK and focus on recent in vivo studies that have established important functions of the protease in procoagulant and proinflammatory disease states. Targeting PK offers novel strategies not previously appreciated to interfere with thrombosis and vascular inflammation in a broad variety of diseases.