Exploring the dynamics of P300 amplitude in patients with schizophrenia
Exploring the dynamics of P300 amplitude in patients with schizophrenia
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DOI：
10.1016/j.ijpsycho.2011.06.006
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发表时间：
2011-09-01
影响因子：
3
通讯作者：
Marques-Teixeira, Joao
中科院分区：
文献类型：
--
作者：
Almeida, Pedro R.;Vieira, Joana B.;Marques-Teixeira, Joao
本研究探讨了首发精神分裂症患者P300生成的时频动态。一组由40名首发精神分裂症患者和40名对照者组成的小组进行了一项听觉古怪的任务。对单次试验数据进行小波分析，计算P300峰值附近50 ms窗口的delta、theta、alpha、beta和gamma波段的事件相关谱摄动（ERSP）和试验间相位相干性（ITC）。通过相关分析和回归分析，研究功率和同步性对P300振幅的贡献。此外，对比了两个亚样本，其中患者的P300振幅低于或高于对照。P300振幅在患者和对照组之间没有差异。频域分析显示，控制组比患者显示出更大的伽马能量下降。然而，这种伽马活动可能是微跳肌伪影的结果。回归分析表明，P300振幅高度依赖于δ功率和同步。子样本的分析证实，虽然伽马功率差异取决于诊断，但delta和theta同步与P300振幅有关，与诊断无关。(C) 2011 Elsevier B.V.版权所有
This study investigated the time-frequency dynamics of P300 generation in patients with first-onset schizophrenia.A group of 40 patients with first-onset schizophrenia and 40 controls performed an auditory oddball task. Wavelet analysis of the single-trial data was used to compute the Event-Related Spectral Perturbation (ERSP) and the Inter-Trial Phase Coherence (ITC) for the delta, theta, alpha, beta and gamma bands on the 50 ms window around peak P300 amplitude. The contribution of power and synchrony for P300 amplitudes was studied through correlation and regression analysis. Further, two sub-samples in which patients had lower or higher P300 amplitudes than their control match were contrasted.P300 amplitude did not differ between patients and controls. The frequency domain analysis revealed that controls display larger reductions on gamma power than patients. However, this gamma activity might be the result of micro-saccadic muscular artifacts.Regression analysis shows that P300 amplitude is highly dependent on delta power and synchronization. The analysis of the subsamples confirmed that while gamma power differences are dependent on the diagnosis, delta and theta synchronization are related to P300 amplitude, irrespective of diagnosis. (C) 2011 Elsevier B.V. All rights reserved.