Perspective-The Feasibility of Continuous Protein Monitoring in Interstitial Fluid.
Perspective-The Feasibility of Continuous Protein Monitoring in Interstitial Fluid.
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DOI：
10.1149/2754-2726/accd7e
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发表时间：
2023-06-01
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实时连续监测体内蛋白质在个性化医疗应用中具有巨大潜力。不幸的是，一个突出的知识差距存在于基础生物学蛋白质转移和组织液和血液之间的相关性。此外，技术感测将需要基于亲和力的平台，这些平台不能在体内得到稳健的保护，因此将在多天至多周的时间内在灵敏度、寿命和结垢方面受到挑战。在这里，我们使用电化学适体传感器作为一个模型系统，讨论必要的进一步研究，以实现连续的蛋白质传感。连续监测或检测蛋白质。蛋白质连续传感器的生物学挑战。生物传感器的灵敏度、寿命和稳定性是未来研究的领域。
Real-time continuous monitoring of proteins in-vivo holds great potential for personalized medical applications. Unfortunately, a prominent knowledge gap exists in the fundamental biology regarding protein transfer and correlation between interstitial fluid and blood. Additionally, technological sensing will require affinity-based platforms that cannot be robustly protected in-vivo and will therefore be challenged in sensitivity, longevity, and fouling over multi-day to week timelines. Here we use electrochemical aptamer sensors as a model system to discuss further research necessary to achieve continuous protein sensing. Continuous monitoring or sensing of proteins. Biological challenges to continuous sensors for proteins. Biosensor sensitivity, longevity, and antifouling are areas for future research.