Effect of Almond Supplementation on Glycemia and Cardiovascular Risk Factors in Asian Indians in North India with Type 2 Diabetes Mellitus: A 24-Week Study
Effect of Almond Supplementation on Glycemia and Cardiovascular Risk Factors in Asian Indians in North India with Type 2 Diabetes Mellitus: A 24-Week Study
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DOI：
10.1089/met.2016.0066
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发表时间：
2017-03-01
影响因子：
2.1
通讯作者：
Pandey, Ravindra M.
中科院分区：
文献类型：
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作者：
Gulati, Seema;Misra, Anoop;Pandey, Ravindra M.
背景：2型糖尿病（T2 D）的统计数据在印度已经达到了威胁的程度。作为健康生活方式的一部分，适当的饮食干预对于遏制这种疾病的进一步传播至关重要。目的：这项干预前后研究在印度新德里进行，旨在调查T2 D受试者每天食用杏仁24周的影响，特别是对心血管疾病（CVD）风险因素的测量。方法和研究设计：在这项研究中，24周的干预期之前是3周的控制饮食和运动磨合期。生杏仁（20%的能量摄入）提供给患者消费沿着饮食和体力活动咨询。对患者进行了人体测量、血压、心率、血压、心率和心率的测量。（空腹血糖、糖化血红蛋白）、脂质[总胆固醇（TC）、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、脂蛋白（a）]、动脉粥样硬化的替代标志物（脉搏波速度）和炎症标志物（高敏C反应蛋白[hs-CRP]）在基线和干预期后。干预后腰围、腰围/身高比、腰围
Background: Type 2 diabetes (T2D)statistics have reached menacing proportions in India. Appropriate dietary intervention, as part of healthy lifestyle, is imperative to curb further spread of this disease.Objectives: This pre-post intervention study was conducted in New Delhi, India, to investigate the effects of daily consumption of almonds for 24 weeks in T2D subjects, specifically on measures of glycemia and cardiovascular disease (CVD) risk factors.Methods and Study Design: In this study, the 24-week intervention period was preceded by a control diet and exercise run-in period of 3 weeks. Raw almonds (20% of energy intake) were provided to the patients for consumption along with diet and physical activity counseling. Patients were assessed for anthropometry, blood pressure, measures of glycemia (fasting blood glucose, glycosylated hemoglobin), lipids [ total cholesterol (TC), triglycerides, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, lipoprotein(a)], surrogate marker of atherosclerosis (Pulse wave velocity), and marker of inflammation (high sensitivity C-reactive protein [hs-CRP]) at baseline and after the intervention period.Results: Statistically significant improvement in mean values for various parameters post intervention was as follows: waist circumference (P < 0.03), waist-to-height ratio (P