8-OH-DPAT MICROINJECTED IN THE REGION OF THE DORSAL RAPHE NUCLEUS BLOCKS AND REVERSES THE ENHANCEMENT OF FEAR CONDITIONING AND INTERFERENCE WITH ESCAPE PRODUCED BY EXPOSURE TO INESCAPABLE SHOCK
8-OH-DPAT MICROINJECTED IN THE REGION OF THE DORSAL RAPHE NUCLEUS BLOCKS AND REVERSES THE ENHANCEMENT OF FEAR CONDITIONING AND INTERFERENCE WITH ESCAPE PRODUCED BY EXPOSURE TO INESCAPABLE SHOCK
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DOI：
10.1037/0735-7044.109.3.404
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发表时间：
1995-06-01
影响因子：
1.9
通讯作者：
WATKINS, LR
中科院分区：
文献类型：
--
作者：
MAIER, SF;GRAHN, RE;WATKINS, LR
先前的研究表明，在不可避免的电击（IS）暴露期间或在随后的行为测试期间，中缝背核（DRN）的抑制可能会阻止IS的通常行为后果。5-HT1A激动剂8-OH-DPAT在暴露于IS之前或在24小时后进行恐惧条件反射和逃避学习测试之前被微注射到DRN区域。它增强了恐惧条件反射，干扰了逃跑行为。在drn内给药8-OH-DPAT完全阻止了这些影响。低而不高的全身剂量8-OH-DPAT也有类似的效果，这支持了有效作用部位在突触前的观点。讨论了这些数据与8-OH-DPAT其他效应之间的关系。
Prior work suggests that inhibition of the dorsal raphe nucleus (DRN) either during exposure to inescapable electric shock (IS) or during later behavioral testing might block the usual behavioral consequences of IS. The 5-HT1A agonist 8-OH-DPAT was microinjected into the region of the DRN either before exposure to IS or before testing for fear conditioning and escape learning conducted 24 hr later. IS potentiated fear conditioning and interfered with escape performance. These effects were completely prevented by intra-DRN administration of 8-OH-DPAT at either point. Low but not high systemic doses of 8-OH-DPAT had a similar effect, supporting the idea that the effective site of action is presynaptic. The relation between these data and other effects of 8-OH-DPAT is discussed.