Tonic function of nicotinic receptors in stress-induced release of L-DOPA from the nucleus accumbens in freely moving rats.
Tonic function of nicotinic receptors in stress-induced release of L-DOPA from the nucleus accumbens in freely moving rats.
复制标题
烟碱受体在应激诱导的自由活动大鼠伏隔核释放 L-DOPA 中的强直功能。
DOI：
10.1016/s0014-2999(01)01174-8
复制
发表时间：
2001
影响因子：
5
通讯作者：
Y. Goshima
中科院分区：
文献类型：
--
作者：
K. Yamanashi;T. Miyamae;Y. Misu;Y. Goshima
我们研究了应激是否会诱导清醒大鼠伏核释放 l-3,4-二羟基苯丙氨酸 (DOPA) 和多巴胺，并表征应激诱导的反应。通过微透析测量，足部电击应激诱导自由活动大鼠的伏核释放多巴和多巴胺。用美加明预处理大鼠完全阻断应激诱导的多巴释放，但仅部分阻断多巴胺释放。地西泮不影响足部电击引起的多巴释放，而相同剂量的地西泮部分阻断应激引起的多巴胺释放。这些发现表明，在意识清醒的大鼠中，应激诱导的伏核释放多巴时，中枢烟碱受体具有强直功能。
We investigated whether stress induces the release of l-3,4-dihydroxyphenylalanine (DOPA) and dopamine from the nucleus accumbens in conscious rats and characterized the stress-induced response. Electrical foot-shock stress induced both DOPA and dopamine release, measured by microdialysis, from the nucleus accumbens in freely moving rats. Pretreatment of rats with mecamylamine completely blocked stress-induced DOPA release, but only partially blocked dopamine release. Diazepam did not affect the foot-shock-induced release of DOPA, while the same dose of diazepam partially blocked the stress-induced release of dopamine. These findings suggest a tonic function of central nicotinic receptors in stress-induced DOPA release from the nucleus accumbens in conscious rats.