Telomere diseases.
Telomere diseases.
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DOI：
10.1056/nejmra0903373
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发表时间：
2009-12-10
期刊：
影响因子：
--
通讯作者：
Young NS
中科院分区：
文献类型：
--
作者：
Calado RT;Young NS
2009年诺贝尔生理学或医学奖最近授予了三位科学家，以表彰他们对端粒（染色体尖端的重复DNA结构）和端粒酶的研究。端粒保护基因组免受遗传物质的损失。这篇综述叙述了端粒的医学意义，并着重于一组疾病，其中端粒的损失似乎是因果关系。
The Nobel Prize in Physiology or Medicine 2009 was recently awarded to three scientists for their work on telomeres, which are repetitive DNA structures at the tips of chromosomes, and the enzyme telomerase. Telomeres protect the genome from loss of genetic material. This review recounts the medical implications of telomeres and focuses on a group of diseases in which the loss of telomeres appears to be causal.