The molecular basis of endothelial cell plasticity.
The molecular basis of endothelial cell plasticity.
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DOI：
10.1038/ncomms14361
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发表时间：
2017-02-09
影响因子：
16.6
通讯作者：
Simons M
中科院分区：
文献类型：
--
作者：
Dejana E;Hirschi KK;Simons M
内皮细胞具有显著的可塑性。在胚胎中，原始内皮细胞分化以获得动脉、静脉或淋巴的命运。某些内皮细胞还经历造血转化，产生多谱系造血干细胞和祖细胞，而其他内皮细胞获得心脏发育所必需的间充质性质。在成人中，维持分化的内皮状态是一个需要持续信号输入的主动过程。如果不能这样做，则会导致内皮细胞向间充质细胞转化，这在许多疾病的发病机制中起重要作用。更好地了解这些表型变化可能会导致新的治疗干预措施的发展。血管内皮对周围环境的提示具有显着的可塑性，导致不同血管床中的内皮细胞具有很大的异质性。在这里，作者解释了胚胎发生过程中和各种疾病中内皮可塑性的分子基础。
The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also undergo hematopoietic transition giving rise to multi-lineage hematopoietic stem and progenitors while others acquire mesenchymal properties necessary for heart development. In the adult, maintenance of differentiated endothelial state is an active process requiring constant signalling input. The failure to do so leads to the development of endothelial-to-mesenchymal transition that plays an important role in pathogenesis of a number of diseases. A better understanding of these phenotypic changes may lead to development of new therapeutic interventions. Vascular endothelium possesses remarkable plasticity in response to cues from its surroundings, leading to great heterogeneity of endothelial cells in different vascular beds. Here the authors explain the molecular basis of endothelial plasticity during embryogenesis and in various diseases.