The InterPro database, an integrated documentation resource for protein families, domains and functional sites
The InterPro database, an integrated documentation resource for protein families, domains and functional sites
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DOI：
10.1093/nar/29.1.37
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发表时间：
2001-01-01
影响因子：
14.9
通讯作者：
Zdobnov, EM
中科院分区：
文献类型：
--
作者：
Apweiler, R;Attwood, TK;Zdobnov, EM
特征数据库是识别新序列中的远缘关系并由此推断蛋白质功能的重要工具。InterPro是蛋白质家族、结构域和功能位点的综合文献资源，它融合了PROSITE、PRINTS、Pfam和ProDom数据库项目的成果。每个InterPro条目包括功能描述、注释、参考文献和相关成员数据库的链接。InterPro 2.0版（2000年10月）包含超过3000个条目，代表了由总共6804种不同的正则表达式、配置文件、指纹和隐马尔可夫模型编码的家族、结构域、重复序列和翻译后修饰位点。每个InterPro条目列出了针对SWISS-PROT和TrEMBL的所有匹配（来自SWISS-PROT和TrEMBL中的462500个蛋白质的超过1000000个命中）。该数据库可在http://www.ebi.ac.uk/interpro/上进行基于文本和序列的搜索。问题可以通过电子邮件发送到interhelp@ebi.ac.uk。
Signature databases are vital tools for identifying distant relationships in novel sequences and hence for inferring protein function. InterPro is an integrated documentation resource for protein families, domains and functional sites, which amalgamates the efforts of the PROSITE, PRINTS, Pfam and ProDom database projects. Each InterPro entry includes a functional description, annotation, literature references and links back to the relevant member database(s). Release 2.0 of InterPro (October 2000) contains over 3000 entries, representing families, domains, repeats and sites of post-translational modification encoded by a total of 6804 different regular expressions, profiles, fingerprints and Hidden Markov Models. Each InterPro entry lists all the matches against;SWISS-PROT and TrEMBL (more than 1 000 000 hits from 462 500 proteins in SWISS-PROT and TrEMBL). The database is accessible for text- and sequence-based searches at http://www.ebi.ac.uk/interpro/. Questions can be emailed to interhelp@ebi.ac.uk.