Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers
Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers
复制标题
DOI：
10.4161/org.6.4.12909
复制
发表时间：
2010-10
期刊：
影响因子：
2.3
通讯作者：
Jane Wang;C. Bettinger;R. Langer;J. Borenstein
中科院分区：
文献类型：
--
作者：
Jane Wang;C. Bettinger;R. Langer;J. Borenstein
具有高机械强度、柔韧性和光学透明度、最佳降解性能和生物相容性的生物可降解聚合物是组织工程装置和药物递送系统成功的关键。大多数可生物降解的聚合物由于在植入时快速降解、极高的刚度和用化学部分使表面官能化的能力有限而具有短的半衰期。本工作描述了由聚（酯酰胺），聚（1，3-二氨基-2-羟基丙烷-co-多元醇癸二酸酯）（APS），最近开发的生物可降解的弹性体聚（酯酰胺）的微流体网络的制造。由APS构建的微流体支架表现出比先前报道的系统低得多的杨氏模量和显著更长的降解半衰期。该装置是使用改良的复制成型技术制造的，该技术快速，廉价，可重复，可扩展，使该方法成为快速成型和制造组织工程支架的理想方法。
Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. Most biodegradable polymers suffer from a short half life due to rapid degradation upon implantation, exceedingly high stiffness, and limited ability to functionalize the surface with chemical moieties. This work describes the fabrication of microfluidic networks from poly(ester amide), poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) (APS), a recently developed biodegradable elastomeric poly(ester amide). Microfluidic scaffolds constructed from APS exhibit a much lower Young’s Modulus and a significantly longer degradation half-life than those of previously reported systems. The device is fabricated using a modified replica-molding technique, which is rapid, inexpensive, reproducible, and scalable, making the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds.