Comparison of the Usefulness of the PHQ-8 and PHQ-9 for Screening for Major Depressive Disorder: Analysis of Psychiatric Outpatient Data
Comparison of the Usefulness of the PHQ-8 and PHQ-9 for Screening for Major Depressive Disorder: Analysis of Psychiatric Outpatient Data
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DOI：
10.30773/pi.2019.02.01
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发表时间：
2019-04-01
影响因子：
2.7
通讯作者：
Han, Changsu
中科院分区：
文献类型：
--
作者：
Shin, Cheolmin;Lee, Seung-Hoon;Han, Changsu
目的探讨患者健康问卷（PHQ-8）作为重性抑郁障碍（MDD）筛查工具的价值。采用简易国际神经精神访谈法诊断抑郁症。我们推导了PHQ-8和PHQ-9的效度和信度。为评价PHQ-8和PHQ-9对抑郁症的鉴别能力，绘制受试者工作特征（ROC）曲线，并比较两个量表的曲线下面积（AUC）。PHQ-8和PHQ-9的Cronbach’s分别为0.892和0.876。与PHQ-9相似，在相关性分析中，PHQ-8也与汉密尔顿抑郁量表评分相关。当我们绘制PHQ-8和PHQ-9的ROC曲线时，AUC没有统计学显著差异。以10分为界值，PHQ-8的敏感性为58.3%，特异性为83.1%，阳性预测值为53.4%，阴性预测值为85.7%。
Objective This study aimed to demonstrate that the Patient Health Questionnaire (PHQ)-8 is not less useful than the PHQ-9 as a screening test for major depressive disorder (MDD).Methods We performed a retrospective analysis of 567 patients in psychiatric outpatient units. The Mini International Neuropsychiatric Interview was used to diagnose MDD. We derived the validity and reliability of the PHQ-8 and PHQ-9. To evaluate the ability of the PHQ-8 and PHQ-9 to discriminate MDD, we drew receiver operating characteristic (ROC) curves and compared the areas under the curves (AUCs).Results Of the 567 participants, 207 (36.5%) were diagnosed with MDD. Cronbach's as for the PHQ-8 and PHQ-9 were 0.892 and 0.876, respectively. Similar to the PHQ-9, the PHQ-8 was also associated with scores on the Hamilton Depression Rating Scale in a correlation analysis. When we drew ROC curves for the PHQ-8 and PHQ-9, there was no statistically significant difference in the AUCs. With a cutoff score of 10, the PHQ-8 showed a sensitivity of 58.3%, specificity of 83.1%, positive predictive value of 53.4%, and negative predictive value of 85.7%.Conclusion In a psychiatric outpatient sample, the PHQ-8 was as useful as the PHQ-9 for MDD screening.