Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia.
Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia.
复制标题
DOI：
10.1001/archpsyc.1995.03950190032005
复制
发表时间：
1995-07
影响因子：
--
通讯作者：
Daniel C. Javitt;Paolina Doneshka;Sandra Grochowski;Walter Ritter
中科院分区：
文献类型：
--
作者：
Daniel C. Javitt;Paolina Doneshka;Sandra Grochowski;Walter Ritter
背景P300(P3)受损是精神分裂症患者脑功能障碍最可靠的指标之一。这项研究调查了P3之前的认知事件相关电位的完整性，以确定精神分裂症患者听觉信息处理受损的最早阶段。方法分别记录20例接受药物治疗的慢性精神分裂症患者、11例停药患者和11例健康志愿者的认知事件相关电位成分，包括失配负波(MMN)、N_2和P_3。记录是在被动和主动反应条件下进行的。比较MMN、N_2和P_3波幅，MMN缺失的程度与P_3降低的程度作为诊断组的函数相关。结果精神分裂症患者在MMN、N_2和P3的产生方面存在严重的障碍。跨组间，MMN波幅的降低与P3波幅的降低显著相关。MMN地形图的组间差异无统计学意义。结论本研究表明，精神分裂症相关的神经生理缺陷普遍存在，甚至延伸到感觉皮质水平。不匹配负值是指自动警报机制的功能，该机制旨在刺激个人探索意想不到的环境事件。这一机制的功能障碍可能导致与精神分裂症相关的缺陷状态。
BACKGROUND Impaired P300 (P3) generation is one of the most robust indices of brain dysfunction in schizophrenia. This study investigates the integrity of cognitive event-related potentials that precede P3 in an "oddball" paradigm to determine the earliest stages at which auditory information processing is impaired in schizophrenia. METHODS Cognitive event-related potential components including mismatch negativity (MMN), N2, and P3 were recorded from subjects with chronic schizophrenia who were receiving medication (n = 20), from those who were withdrawn from drug treatment (n = 11), and from healthy volunteers (n = 11) during an auditory oddball paradigm. Recordings were made in both passive and active response conditions. The MMN, N2, and P3 amplitudes were compared across groups and the degree of MMN deficit was correlated with the degree of P3 reduction as a function of diagnostic group. RESULTS Schizophrenic subjects showed severe impairments in the generation of MMN and N2 as well as P3. Across groups, the decrement in MMN amplitude correlated significantly with the decrement in P3 amplitude. There were no significant between-group differences in MMN topography. CONCLUSIONS The present study demonstrates that the neurophysiological deficits associated with schizophrenia, as reflected in cognitive event-related potential generation, are pervasive, extending even to the level of the sensory cortex. Mismatch negativity indexes the functioning of an automatic alerting mechanism designed to stimulate individuals to explore unexpected environmental events. Dysfunction of this mechanism may contribute to the deficit state associated with schizophrenia.