Quality of life in dementia: care recipient and caregiver perceptions of quality of life in dementia: the LASER-AD study
Quality of life in dementia: care recipient and caregiver perceptions of quality of life in dementia: the LASER-AD study
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DOI：
10.1002/gps.1786
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发表时间：
2007-10-01
影响因子：
4
通讯作者：
Livingston, Gill
中科院分区：
文献类型：
--
作者：
Hoe, Juanita;Katona, Cornelius;Livingston, Gill
生活质量（QoL）是痴呆症的一个关键结果。目的比较护理接受者（CR）和照顾者（CG）对CR的生活质量（QOL）的看法，并找出决定因素。方法CR和CGS完成生活质量-阿尔茨海默病（QOL-AD）量表。CR的决定因素和CGS对生活质量的看法存在差异。当CR有较少的抑郁症状、较少的易怒、较少的冷漠、较少的日常生活障碍和住在家里时，家庭CG评定CR的生活质量较高。较少的抑郁症状，住在家里，服用乙酰胆碱酯酶抑制剂（AChEI）预测较高的CR评定QoL.Conclusion代理评级在痴呆症不复制CR的QoL的意见。这是第一项对服用乙酰胆碱酯酶的痴呆症患者采用经验证的生活质量指标的研究。在得出关于其对生活质量影响的结论之前，需要进行随机对照试验。由于QoL旨在反映心理和身体症状的影响，因此应谨慎解释QoL与症状之间的相关性。版权所有（c）2007约翰威利父子有限公司。
Background Quality of Life (QoL) is a key outcome in dementia. Aim To compare care recipients' (CR) and caregivers' (CG) views on CRs' QoL and identify determinants.Methods CRs and CGS completed the Quality of Life - Alzheimer's Disease (QOL-AD) scale.Results One hundred and ninety-one CR/CG dyads were interviewed. There were differences between determinants of the CRs and CGS views about QoL. Family-CGs rated CRs' QoL higher when CRs had fewer depressive symptoms, less irritability, less apathy, less daily living impairment and lived at home. Fewer depressive symptoms, living at home and taking acetylcholinesterase-inhibitors (AChEI) predicted higher CR rated QoL.Conclusion Proxy ratings in dementia do not replicate CRs' views of QoL. This is the first study to employ a validated QoL measure for people with dementia taking AChEls. Randomised controlled trials are needed before drawing conclusions about their effect on QoL. Interpretation of correlations between QoL and symptoms should be cautious as QoL is designed to reflect the impact of psychological and physical symptoms. Copyright (c) 2007 John Wiley & Sons, Ltd.