Estrogenic activity associated with organochlorine compounds in fish extracts from European mountain lakes
Estrogenic activity associated with organochlorine compounds in fish extracts from European mountain lakes
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DOI：
10.1016/j.envpol.2006.05.021
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发表时间：
2007-02-01
影响因子：
8.9
通讯作者：
Pina, Benjamin
中科院分区：
文献类型：
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作者：
Garcia-Reyero, Natalia;Grimalt, Joan O.;Pina, Benjamin
对欧洲10个山湖鱼肌提取物的有机氯化合物（OCs）和雌激素活性进行了分析，后者采用基于人雌激素受体的重组酵母试验。70%的样本显示雌激素活性高于检测极限，5个样本的一个子集显示雌激素活性，相当于超过10,000 pg/g雌二醇。这些高雌激素样本出现在两个湖泊，塔特拉山脉的Velke Hincovo和比利牛斯山脉的Redon。主成分分析将肌肉提取物的雌激素活性与鱼龄和多氯联苯（PCBs）浓度相关。这与先前观察到的多氯联苯与鱼龄的相关性是一致的。此外，大多数具有高雌激素活性的鱼类都是在沉积物中含有高OC含量的湖泊中发现的，这进一步证明了大气中人为污染物的沉积是导致所观察到的内分泌干扰效应的主要过程。(c) 2006 Elsevier Ltd.版权所有。
Fish muscle extracts from ten European mountain lakes were analyzed for organochlorine compounds (OCs) and estrogenic activity, the latter by a recombinant yeast assay based on the human estrogen receptor. Seventy percent of the samples showed estrogenic activity above detection limits and a subset of five samples showed estrogenic activities, equivalent to more than 10,000 pg/g of estradiol. These highly estrogenic samples occurred in two lakes, Velke Hincovo in the Tatra Mountains and Redon in the Pyrenees. Principal component analysis correlated estrogenic activity of muscle extracts to fish age and concentrations of the more chlorinated polychlorobiphenyls (PCBs). This is consistent with previously observed correlations of these PCBs with fish age. In addition, most fish with high estrogenic activity were found in lakes containing high OC levels in the sediments, which gives further ground to atmospheric deposition of anthropogenic pollutants as main process leading to the observed endocrine disruption effects. (c) 2006 Elsevier Ltd. All rights reserved.