A CCL8 gradient drives breast cancer cell dissemination.
A CCL8 gradient drives breast cancer cell dissemination.
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作者：
癌细胞向化学吸引因子梯度的迁移代表了一种潜在的，但难以捉摸的，可能有助于癌细胞传播的机制。在这里，我们提供的证据，为维持梯度增加CCL8浓度之间的上皮，基质和周边，这是有助于乳腺癌细胞的传播。响应于由肿瘤上皮引起的信号，在肿瘤边缘的基质成纤维细胞中以及在乳腺癌细胞倾向于转移的组织如肺和脑中，CCL8的产生增强。对CCL8活性的操纵影响肿瘤的组织学，并促进转移过程的主要步骤，例如侵袭邻近基质、内渗和最终外渗和播种。这些发现阐明了诸如CCL8等化学吸引因子的梯度如何驱动转移，并表明干扰其操作可能为乳腺癌管理提供手段。
The migration of cancer cells towards gradients of chemoattractive factors represents a potential, yet elusive, mechanism that may contribute to cancer cell dissemination. Here we provide evidence for the maintenance of a gradient of increasing CCL8 concentration between the epithelium, the stroma and the periphery that is instrumental for breast cancer cells’ dissemination. In response to signals elicited by the neoplastic epithelium CCL8 production is enhanced in stromal fibroblasts at the tumor margins and in tissues at which breast cancer cells tend to metastasize such as the lungs and the brain. Manipulation of CCL8 activity influences the histology of the tumors and promotes major steps of the metastatic process such as invasion to adjacent stroma, intravasation and ultimately extravasation and seeding. These findings exemplify how gradients of chemoattractive factors such as CCL8, drive metastasis and suggest that interference with their operation may provide means for breast cancer management.
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影响因子：
45.3
作者：
Cristofanilli, M;Hayes, DF;Terstappen, LWMM
通讯作者：
Terstappen, LWMM
影响因子：
64.5
作者：
Hu B;Castillo E;Harewood L;Ostano P;Reymond A;Dummer R;Raffoul W;Hoetzenecker W;Hofbauer GF;Dotto GP
通讯作者：
Dotto GP
影响因子：
4.6
作者：
Hollmén M;Roudnicky F;Karaman S;Detmar M
通讯作者：
Detmar M
影响因子：
4.6
作者：
Fenner J;Stacer AC;Winterroth F;Johnson TD;Luker KE;Luker GD
通讯作者：
Luker GD
影响因子：
4.8
作者：
Gong, WH;Howard, OMZ;Wang, JM
通讯作者：
Wang, JM