A heterogeneous population code for elapsed time in rat medial agranular cortex.
A heterogeneous population code for elapsed time in rat medial agranular cortex.
复制标题
大鼠内侧无颗粒皮层经过时间的异质群体代码。
DOI：
10.1037/a0021954
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发表时间：
2011
影响因子：
1.9
通讯作者：
Rinzel,John
中科院分区：
文献类型：
--
作者：
Matell,MatthewS;Shea-Brown,Eric;Gooch,Cindy;Wilson,AGeorge;Rinzel,John
行为时间控制的神经机制在很大程度上是未知的。在这里，我们记录了大鼠的内侧无颗粒皮质神经元，当它们在一个时间产生任务，即峰值间隔过程中自由表现时。由于估计食物供应时间的可变性，强烈的反应通常包括预期的持续时间，在发出信号的延迟之前一段时间开始，在信号延迟后一段时间结束。这些响应期提供了分析性的“稳定状态”窗口，在此期间，受试者主动表明他们对食物可获得性的时间预期。值得注意的是，在这些反应期内，可以看到各种不同的放电模式，大致可以描述为坡度、峰值和低谷，具有不同的斜率、方向和出现最大或最小值的时间。正则化线性判别分析表明，这些模式提供了足够可靠的信息来区分在这些反应期内经过的反应持续时间。对神经元变异性进行建模表明，在不同时间使用不同斜率和最小/最大速率的斜坡、斜坡和峰值，导致了时间预测误差的显著改善，这表明过去时间的神经表示的异质性可能有助于时间控制的行为。(心理信息数据库记录(C)2020 APA，版权所有)
The neural mechanisms underlying the temporal control of behavior are largely unknown. Here we recorded from medial agranular cortex neurons in rats while they freely behaved in a temporal production task, the peak-interval procedure. Due to variability in estimating the time of food availability, robust responding typically bracketed the expected duration, starting some time before and ending some time after the signaled delay. These response periods provided analytic “steady state” windows during which subjects actively indicated their temporal expectation of food availability. Remarkably, during these response periods, a variety of firing patterns were seen that could be broadly described as ramps, peaks, and dips, with different slopes, directions, and times at which maxima or minima occur. Regularized linear discriminant analysis indicated that these patterns provided sufficiently reliable information to discriminate the elapsed duration of responding within these response periods. Modeling this across neuron variability showed that the utilization of ramps, dips, and peaks, with different slopes and minimal/maximal rates at different times, led to a substantial improvement in temporal prediction errors, suggesting that heterogeneity in the neural representation of elapsed time may facilitate temporally controlled behavior.(PsycInfo Database Record (c) 2020 APA, all rights reserved)