SUBSTANCE-P AND PAIN - AN UPDATING
SUBSTANCE-P AND PAIN - AN UPDATING
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DOI：
10.1016/0166-2236(80)90036-3
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发表时间：
1980-01-01
影响因子：
15.9
通讯作者：
HENRY, JL
中科院分区：
文献类型：
--
作者：
HENRY, JL
P物质（Substance P）最初由Yon Euler和Gaddum于1931年发现，经过40多年的研究才被认为是哺乳动物中枢神经系统突触传递中的一种重要的天然肽。在它的各种可能的作用中，也许最明确的实验证据是它参与了通过脊髓传递疼痛信息的门控。这里詹姆斯L.亨利描述了这个结论是如何得出的。
Substance P, discovered originally in 1 931 by yon Euler and Gaddum, has taken over 40 years to be appreciated as an important naturally-occurring peptide in synaptic transmiT-sion in the mammalian central nervous system. Of its vario~ possible roles, perhaps the most clearly substantiated by experimental evidence is its" involvement in gating the transfer of pain information through the spinal cord. Here James L. Henry describes how this conclusion has been arrived at.