The Unwanted Cell Migration in the Brain: Glioma Metastasis
The Unwanted Cell Migration in the Brain: Glioma Metastasis
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大脑中不需要的细胞迁移：神经胶质瘤转移
DOI：
10.1007/s11064-017-2272-2
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发表时间：
2017-06-01
影响因子：
4.4
通讯作者：
Yu, Albert Cheung Hoi
中科院分区：
文献类型：
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作者：
Qi, Xue Tao;Zhan, Jiang Shan;Yu, Albert Cheung Hoi
细胞迁移被认为是一个高度协调的过程。它是组织形态发生、伤口愈合和免疫应答的基础和基本现象。在失调下，它有助于癌症转移。脑是人体内最复杂的器官，含有多种神经细胞，其中星形胶质细胞在生理和病理功能的监测中起着至关重要的作用。星形细胞瘤起源于星形胶质细胞，其最恶性的类型是多形性胶质母细胞瘤（WHO IV级星形细胞瘤），其能够广泛浸润到邻近的脑组织中，使得完全切除肿瘤是不可能的。最近，我们综述了星形胶质细胞迁移的机制。鉴于星形细胞瘤与星形胶质细胞具有许多共同的组织学特征，因此我们试图回顾胶质瘤细胞迁移的机制，并将其与正常星形胶质细胞进行比较，希望更好地了解导致其脑转移的迁移机制失调。
Cell migration is identified as a highly orchestrated process. It is a fundamental and essential phenomenon underlying tissue morphogenesis, wound healing, and immune response. Under dysregulation, it contributes to cancer metastasis. Brain is considered to be the most complex organ in human body containing many types of neural cells with astrocytes playing crucial roles in monitoring both physiological and pathological functions. Astrocytoma originates from astrocytes and its most malignant type is glioblastoma multiforme (WHO Grade IV astrocytoma), which is capable to infiltrate widely into the neighboring brain tissues making a complete resection of tumors impossible. Very recently, we have reviewed the mechanisms for astrocytes in migration. Given the fact that astrocytoma shares many histological features with astrocytes, we therefore attempt to review the mechanisms for glioma cells in migration and compare them to normal astrocytes, hoping to obtain a better insight into the dysregulation of migratory mechanisms contributing to their metastasis in the brain.