Review series: TOR kinase complexes and cell migration.

Review series: TOR kinase complexes and cell migration.
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DOI:
10.1083/jcb.201102090
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发表时间:
2011-09-19
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Parent CA
Parent CA
中科院分区:
其他
文献类型:
--
作者:
Liu L;Parent CA

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细胞迁移是广泛的生物和病理反应的一个基本过程。它受复杂的信号转导通路调节,以响应外部信号,偶联生长因子和趋化因子受体。近年来,雷帕霉素(TOR)激酶靶点作为TOR复合物1 (TORC1)或TOR复合物2 (TORC2)的一部分,已被证明是多种细胞类型和生物体中连接外部信号与细胞骨架机制的重要信号传导成分。因此,这些复合物已成为细胞迁移和趋化的关键调节因子。
Cell migration is a fundamental process in a wide array of biological and pathological responses. It is regulated by complex signal transduction pathways in response to external cues that couple to growth factor and chemokine receptors. In recent years, the target of rapamycin (TOR) kinase, as part of either TOR complex 1 (TORC1) or TOR complex 2 (TORC2), has been shown to be an important signaling component linking external signals to the cytoskeletal machinery in a variety of cell types and organisms. Thus, these complexes have emerged as key regulators of cell migration and chemotaxis.
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