The common enteric bacterial pathogens and their antimicrobial susceptibility pattern among HIV-infected individuals attending the antiretroviral therapy clinic of Hawassa university hospital, southern Ethiopia
The common enteric bacterial pathogens and their antimicrobial susceptibility pattern among HIV-infected individuals attending the antiretroviral therapy clinic of Hawassa university hospital, southern Ethiopia
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DOI：
10.1186/s13756-017-0288-7
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发表时间：
2017-12-22
影响因子：
5.5
通讯作者：
Shimelis, Techalew
中科院分区：
文献类型：
--
作者：
Kebede, Ayele;Aragie, Solomon;Shimelis, Techalew
背景资料：艾滋病毒感染者中细菌性胃肠炎的频繁发生，加上抗微生物药物耐药性的增加，对发展中国家的公共卫生构成重大挑战。本研究的目的是确定肠道细菌病原体的患病率和抗菌药物的敏感性模式之间的艾滋病毒感染的患者在三级医院在南部Ethiopia.Methods：一个基于医院的横断面研究进行了在Hawassa大学综合专科医院从2016年2月至5月。一个连续的215例HIV感染者，胃肠道疾病的投诉，入组。社会人口学和相关因素的数据收集使用结构式问卷。从每名研究参与者采集粪便样本，并进行培养以分离肠道细菌病原体;使用生化试验对分离株进行表征。结果：在215例患者中，27例（12.6%）为各种细菌病原体培养阳性。弯曲杆菌属是最常见的细菌分离株（6.04%），其次是沙门氏菌属（5.1%）。大多数菌株对诺氟沙星、萘啶酸、庆大霉素、头孢曲松和环丙沙星敏感，对甲氧苄啶、磺胺甲恶唑和氯霉素耐药。食用生食是唯一与肠道细菌感染显著相关的危险因素（粗比值比3.41，95%CI 1.13-10.3）。结论：肠道致病菌的检出率及其对常用抗生素的耐药模式，提示应加强干预力度，促进合理使用抗菌药物。在这方面，应强调加强抗菌药物管理工作的必要性，以减缓这一人群中抗菌药物耐药性的增长。
Background: The frequent occurrence of bacterial gastroenteritis among HIV-infected individuals together with increased antimicrobial drug resistance pose a significant public health challenge in developing countries. This study aimed to determine the prevalence of enteric bacterial pathogens and their antimicrobial susceptibility pattern among HIV-infected patients in a tertiary hospital in southern Ethiopia.Methods: A hospital-based cross-sectional study was conducted at Hawassa University Comprehensive Specialized Hospital from February to May, 2016. A consecutive 215 HIV-infected patients, with complaints of gastrointestinal tract disease, were enrolled. Data on socio-demography and related factors was collected using a structured questionnaire. A stool sample was collected from each study participant and cultured to isolate enteric bacterial pathogens; isolates were characterized using biochemical tests. Antimicrobial susceptibility was determined using the Kirby-Bauer disk diffusion technique.Results: Out of 215 patients, 27(12.6%) were culture positive for various bacterial pathogens. Campylobacter species was the most common bacterial isolate (6.04%), followed by Salmonella species (5.1%). The majority of isolates was sensitive to norfloxacin, nalidixic acid, gentamicin, ceftriaxone and ciprofloxacin and showed resistance to trimethoprim sulfamethoxazole (SXT) and chloramphenicol. Consumption of raw food was the only risk factor found to be significantly associated with enteric bacterial infection (crude odds ratio 3.41 95% CI 1.13-10.3).Conclusions: The observed rate of enteric bacterial pathogens and their antimicrobial resistance pattern to the commonly prescribed antibiotics highlights the need to strengthen intervention efforts and promote rational use of antimicrobials. In this regard, the need to strengthen antimicrobial stewardship efforts should be emphasized to slow grown antimicrobial resistance among this population group.