Low plasma antioxidant activity is associated with high lesion volume and neurological impairment in stroke
Low plasma antioxidant activity is associated with high lesion volume and neurological impairment in stroke
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DOI：
10.1161/01.str.31.1.33
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发表时间：
2000-01-01
期刊：
影响因子：
8.3
通讯作者：
Alho, H
中科院分区：
文献类型：
--
作者：
Leinonen, JS;Ahonen, JP;Alho, H
背景和目的：氧化应激可能参与缺血再灌注引起的神经元损伤。本研究的目的是评估抗氧化活性在脑缺血性stroke. Methods中的作用，血浆和脑脊液的抗氧化活性进行了评估，在22例脑半球梗死，这是验证和量化的MRI.Results-Low总过氧自由基捕获潜力的血浆，但不是脑脊液，通过NIH卒中量表、Barthel指数和手运动评分测试评估，与高病变体积和高神经功能缺损相关。血浆中抗坏血酸，α-生育酚和蛋白硫醇的浓度也与神经损伤的程度。结论这些数据表明，血浆的抗氧化活性可能是一个重要的因素，提供保护，从中风相关的氧化应激引起的神经损伤。
Background and Purpose-Oxidative stress is probably involved in neuronal damage induced by ischemia-reperfusion. The purpose of this study was to assess the role of antioxidant activity in cerebral ischemic stroke.Methods-Antioxidant activity of blood plasma and cerebrospinal fluid was assessed in 22 patients with cerebral hemisphere infarction that was verified and quantified by MRI.Results-Low total peroxyl radical trapping potential of plasma, but not of cerebrospinal fluid, was associated with high lesion volume and high neurological impairment assessed by scores on NIH Stroke Scale, Barthel Index, and Hand Motor Score tests. The plasma concentrations of ascorbic acid, alpha-tocopherol, and protein thiols were also associated with the degree of neurological impairment.Conclusions-These data suggest that the antioxidant activity of plasma may be an important factor providing protection from neurological damage caused by stroke-associated oxidative stress.