Mechanisms of control of milk intake in suckling rats.
Mechanisms of control of milk intake in suckling rats.
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乳鼠乳汁摄入量的控制机制。
DOI：
10.1152/ajpregu.1983.245.2.r154
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Blass,EM
中科院分区：
文献类型：
--
作者：
Cramer,CP;Blass,EM
为了协调报告的通过哺乳摄入乳汁的内部对照开发差异，允许5-20日龄的幼鼠从麻醉的母鼠中抽取乳汁，通过静脉输注催产素定期诱导母鼠分泌乳汁。在实验1中，通过为幼崽提供一系列充满乳汁的母鼠，使乳汁供应不受限制。5日龄和10日龄的幼犬摄取了不适当的大量乳汁，而15日龄和20日龄的幼犬则将摄入量限制在中等量。在实验2中，摄入量的剥夺和非剥夺幼犬后，只有10催产素诱导的牛奶放下，正常的护理回合。因此，当牛奶供应有限时，所有年龄段的幼犬都会根据他们的剥夺程度消耗大量的牛奶。此外，10-20日龄幼仔的摄入量与乳头移位的发生率高度相关。因此，5日龄的幼鼠可以改变从有限来源吸取乳汁的速率;然而，直到15日龄，它们才能够控制从无限来源吸取的体积。
To reconcile reported differences in the development of internal controls over milk intake via suckling, infant rats 5-20 days of age were allowed to withdraw milk from anesthetized dams periodically induced to let down milk by intravenous infusion of oxytocin. In experiment 1, milk supply was made unlimited by providing pups with a series of milk-replete dams. Five- and ten-day-old pups withdrew inappropriately large volumes of milk, whereas 15- and 20-day-old pups limited intake to moderate volumes. In experiment 2, intake of deprived and nondeprived pups was measured after only 10 oxytocin-induced milk letdowns, comparable to the normal nursing bout. When milk availability was thus limited, pups of all ages consumed volumes of milk dependent on their level of deprivation. Moreover intake of pups 10-20 days of age was highly correlated with incidence of nipple shifting. Thus rats as young as 5 days of age can vary the rate at which milk is taken from a limited source; however, not until 15 days are they able to control the volume withdrawn from an unlimited source.