Connectivity-Based Functional Analysis of Dopamine Release in the Striatum Using Diffusion-Weighted MRI and Positron Emission Tomography
Connectivity-Based Functional Analysis of Dopamine Release in the Striatum Using Diffusion-Weighted MRI and Positron Emission Tomography
复制标题
DOI：
10.1093/cercor/bhs397
复制
发表时间：
2014-05-01
期刊：
影响因子：
3.7
通讯作者：
Gunn, Roger N.
中科院分区：
文献类型：
--
作者：
Tziortzi, Andri C.;Haber, Suzanne N.;Gunn, Roger N.
纹状体与皮质共同作用，控制和执行因帕金森病和精神分裂症等疾病中异常多巴胺神经传递而受损的功能。迄今为止，在体内定量纹状体多巴胺已被限制到基于结构的纹状体细分。在这里，我们提出了一种多模式成像方法，定量的内源性多巴胺释放后，管理的d-安非他明在功能分区的健康人的纹状体与[C-11]PHNO和[C-11]雷氯必利正电子发射断层扫描配体。使用基于连通性（CB）的分割，我们细分的纹状体功能分区的基础上，来自扩散磁共振成像（MRI）和概率纤维束成像的纹状体皮质解剖连接信息。我们的分组表明，纹状体的功能组织在空间上是连贯的个人，与灵长类动物的数据和以前的扩散MRI研究一致，具有独特的和重叠的网络。D-安非他明在边缘系统中诱导最高的多巴胺释放，其次是感觉、运动和执行区域。这些数据表明，D2样受体的相对区域比例不太可能负责这种区域多巴胺释放模式。值得注意的是，多巴胺释放的均匀性显着较高的CB功能细分相比，结构细分。这些结果支持局部多巴胺释放水平与皮质连接指纹之间的关联。
The striatum acts in conjunction with the cortex to control and execute functions that are impaired by abnormal dopamine neurotransmission in disorders such as Parkinsons and schizophrenia. To date, in vivo quantification of striatal dopamine has been restricted to structure-based striatal subdivisions. Here, we present a multimodal imaging approach that quantifies the endogenous dopamine release following the administration of d-amphetamine in the functional subdivisions of the striatum of healthy humans with [C-11]PHNO and [C-11]Raclopride positron emission tomography ligands. Using connectivity-based (CB) parcellation, we subdivided the striatum into functional subregions based on striato-cortical anatomical connectivity information derived from diffusion magnetic resonance imaging (MRI) and probabilistic tractography. Our parcellation showed that the functional organization of the striatum was spatially coherent across individuals, congruent with primate data and previous diffusion MRI studies, with distinctive and overlapping networks. d-amphetamine induced the highest dopamine release in the limbic followed by the sensory, motor, and executive areas. The data suggest that the relative regional proportions of D2-like receptors are unlikely to be responsible for this regional dopamine release pattern. Notably, the homogeneity of dopamine release was significantly higher within the CB functional subdivisions in comparison with the structural subdivisions. These results support an association between local levels of dopamine release and cortical connectivity fingerprints.