Time of day influences stress hormone response to ketamine.
Time of day influences stress hormone response to ketamine.
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一天中的时间影响应力激素对氯胺酮的反应。
DOI：
10.1111/jne.13194
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发表时间：
2022-10
影响因子：
3.2
通讯作者：
Lightman, Stafford L.
中科院分区：
文献类型：
--
作者：
Birnie, Matthew T.;Eapen, Alen, V;Kershaw, Yvonne M.;Lodge, David;Collingridge, Graham L.;Conway-Campbell, Becky L.;Lightman, Stafford L.
超过50%的抑郁症患者表现出下丘脑-垂体-肾上腺（HPA）轴的过度活跃。常规治疗需要数周到数月的时间才能改善症状。氯胺酮具有快速起效的抗抑郁作用。然而，它对HPA轴活动的作用知之甚少。在这里，我们测量了皮质酮（CORT）的氯胺酮在一天中的不同时间给药的Wistar-Kyoto（WKY）大鼠的反应。在雄性大鼠中，使用自动采血系统每10分钟采集一次血液，持续28 h。氯胺酮（5/10/25 mg · kg）在活动期和非活动期两个时间点通过皮下套管输注。使用放射免疫测定法测量响应于氯胺酮的血液中的CORT水平。WKY大鼠表现出强劲的皮质酮昼夜分泌，与Sprague道利大鼠没有太大差异。氯胺酮（所有剂量）在两个输注时间均显著增加CORT反应。然而，当在非活动期给予氯胺酮时，观察到剂量依赖性效应和相对于基线的显著增加。氯胺酮对HPA轴功能具有稳健和快速的影响。氯胺酮注射的时机可能对糖皮质激素介导的抑郁症作用至关重要。超过50%的抑郁症患者表现出HPA轴的过度活跃。氯胺酮具有快速起效的抗抑郁作用，但氯胺酮如何与HPA轴功能相互作用尚不清楚。在这里，我们测量了大鼠在一天中以及在早晨和晚上氯胺酮输注期间的皮质酮释放。我们发现，氯胺酮注入在上午诱导更大的皮质酮反应比在晚上。这些数据表明，一天中的时间可能对糖皮质激素介导的抑郁症作用至关重要。
Over 50% of depressed patients show hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis. Conventional therapy takes weeks to months to improve symptoms. Ketamine has rapid onset antidepressant effects. Yet its action on HPA axis activity is poorly understood. Here, we measured the corticosterone (CORT) response to ketamine administered at different times of day in the Wistar–Kyoto (WKY) rat. In male rats, blood was collected every 10 min for 28 h using an automated blood sampling system. Ketamine (5/10/25 mg · kg) was infused through a subcutaneous cannula at two time points–during the active and inactive period. CORT levels in blood were measured in response to ketamine using a radioimmunoassay. WKY rats displayed robust circadian secretion of corticosterone and was not overly different to Sprague Dawley rats. Ketamine (all doses) significantly increased CORT response at both infusion times. However, a dose dependent effect and marked increase over baseline was observed when ketamine was administered during the inactive phase. Ketamine has a robust and rapid effect on HPA axis function. The timing of ketamine injection may prove crucial for glucocorticoid‐mediated action in depression. Over 50% of depressed patients show hyperactivity of the HPA axis. Ketamine has rapid onset antidepressant effects, yet how ketamine interacts with HPA axis function is unknown. Here, we measured corticosterone release in the rat across the day and during ketamine infusion in the morning and evening. We found that Ketamine infused during the morning induced a greater corticosterone response than in the evening. These data suggest that time of day may be crucial for glucocorticoid‐mediated action in depression.
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影响因子：
4.5
作者：
Flynn BP;Birnie MT;Kershaw YM;Pauza AG;Kim S;Baek S;Rogers MF;Paterson AR;Stavreva DA;Murphy D;Hager GL;Lightman SL;Conway-Campbell BL
通讯作者：
Conway-Campbell BL
影响因子：
11
作者：
Fava M;Freeman MP;Flynn M;Judge H;Hoeppner BB;Cusin C;Ionescu DF;Mathew SJ;Chang LC;Iosifescu DV;Murrough J;Debattista C;Schatzberg AF;Trivedi MH;Jha MK;Sanacora G;Wilkinson ST;Papakostas GI
通讯作者：
Papakostas GI
DOI：
10.1007/bf03011073
发表时间：
1995-11-01
期刊：
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
影响因子：
--
作者：
KOMATSU, T;SINGH, PK;SHIMADA, Y
通讯作者：
SHIMADA, Y
影响因子：
10.6
作者：
aan het Rot, Marije;Collins, Katherine A.;Mathew, Sanjay J.
通讯作者：
Mathew, Sanjay J.
影响因子：
11
作者：
Budzinski, Maia L.;Sokn, Clara;Liberman, Ana C.
通讯作者：
Liberman, Ana C.