Intravenous injection of mesenchymal stem cell spheroids improves the pulmonary delivery and prolongs in vivo survival
Intravenous injection of mesenchymal stem cell spheroids improves the pulmonary delivery and prolongs in vivo survival
复制标题
DOI：
10.1002/biot.202100137
复制
发表时间：
2021-09
影响因子：
4.7
通讯作者：
Yoshihiko Shimazawa;K. Kusamori;M. Tsujimura;Asuka Shimomura;R. Takasaki;Yukiya Takayama;K. Shimizu;Satoshi Konishi;M. Nishikawa
中科院分区：
文献类型：
--
作者：
Yoshihiko Shimazawa;K. Kusamori;M. Tsujimura;Asuka Shimomura;R. Takasaki;Yukiya Takayama;K. Shimizu;Satoshi Konishi;M. Nishikawa
间充质干细胞（mesenchymal stem cell，MSCs）具有良好的治疗潜力，已被广泛应用于多种疾病的治疗。然而，骨髓间充质干细胞移植后的存活率和持续时间分别极低和短。为了解决这些问题，在本研究中，我们制备了多细胞的MSCs球体，并研究了其在小鼠静脉注射后的存活和功能。
Because of the excellent therapeutic potential, mesenchymal stem cells (MSCs) have been used as cell therapeutics for various diseases. However, the survival rate and duration of MSCs after transplantation are extremely low and short, respectively. To solve these problems, in this study, we prepared multicellular spheroids of MSCs and investigated their survival and function after intravenous injection in mice.