SEM observations of surface alterations associated with neural tube closure in the mouse and hamster
SEM observations of surface alterations associated with neural tube closure in the mouse and hamster
复制标题
扫描电镜观察小鼠和仓鼠神经管闭合相关的表面变化
DOI：
10.1002/ar.1091830109
复制
发表时间：
1975
期刊：
影响因子：
--
通讯作者：
R. Waterman
中科院分区：
文献类型：
--
作者：
R. Waterman
脊椎动物神经管的形成和分化已被广泛研究。特别关注的是：（1）下腱索-中胚层诱导神经板增厚;（2）神经褶和神经格罗夫出现的因素;（3）神经嵴细胞从神经褶迁移;（四）神经管壁内的有丝分裂活动和细胞分化的模式导致中枢神经系统的复杂功能形态。神经系统相对较少的注意力已经给出了神经褶皱之间的融合，导致形成一个封闭的神经管的细节（MarinPadilla，'70）。最近用扫描电子显微镜（SEM）观察到小鸡神经管闭合期间与神经褶皱细胞相关的小膜“皱褶”（Revel，'74）。有人建议，这些结构可能发挥作用，形成新的粘连之间的表面并置神经褶皱。本研究报告了在胚胎小鼠和金黄地鼠的神经褶皱融合过程中存在类似的表面改变。
Vertebrate neural tube formation and differentiation have been extensively examined. Particular interest has been paid to : ( 1 ) the induction of a thickened neural plate by subjacent chorda-mesoderm, (2) factors responsible for the appearance of the neural folds and neural grove, ( 3 ) the migration of neural crest cells from the neural folds and, (4) patterns of mitotic activity and cellular differentiation within the walls of the neural tube leading to the complex functional morphology of the central nervous system. Relatively little attention has been given to the details of fusion between the neural folds resulting in formation of a closed neural tube (MarinPadilla, ’70) . Small membrane “ruffles” associated with cells of the neural folds during neural tube closure in the chick were recently observed with the scanning electron microscope (SEM) (Revel, ’74). It was suggested that these structures may play a role in forming new adhesions between the surfaces of apposed neural folds. The present study reports the presence of similar surface alterations during fusion of the neural folds in embryonic mice and golden hamsters.