A report from the LALA-94 and LALA-SA groups on hypodiploidy with 30 to 39 chromosomes and near-triploidy:: 2 possible expressions of a sole entity conferring poor prognosis in adult acute lymphoblastic leukemia (ALL)
A report from the LALA-94 and LALA-SA groups on hypodiploidy with 30 to 39 chromosomes and near-triploidy:: 2 possible expressions of a sole entity conferring poor prognosis in adult acute lymphoblastic leukemia (ALL)
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DOI：
10.1182/blood-2003-04-1299
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发表时间：
2004-10-15
期刊：
影响因子：
20.3
通讯作者：
Dastugue, N
中科院分区：
文献类型：
--
作者：
Charrin, C;Thomas, X;Dastugue, N
为了揭示急性淋巴细胞白血病(ALL)中30~39条染色体的亚二倍体与近三倍体的关系，我们研究了623例成人急性淋巴细胞白血病(ALL)患者中的24例，其中24例表现为其中一种非整倍体。这两个倍体群体的细胞遗传学特征具有惊人的相似性：第2、3、4、7、13、15、16和17号染色体在亚二倍体30~39中表现为显著的单体，在近三倍体中也经常是二体，而在亚二倍体30~39中成对保留的染色体经常是近三倍体中的四倍体。DNA含量数据显示，大多数受试者同时存在两个非整倍体峰(DNA指数：0.72-0.87/1.39-1.89)，细胞遗传学图谱的多重对应分析证实了它们之间的强烈关系。因此，我们假设近三倍体起源于30到39条染色体的亚二倍体的重复，并且这两个非整倍体群体是同一疾病的两种表现。这24例患者表现为B细胞表型，低白细胞(中位白细胞计数，4.2x10(9)/L)，预后较差(完全缓解，57%；中位无病生存，8个月；中位生存，10.4个月)，与Ph+患者按相同方案治疗相当。我们建议将30~39条染色体的亚二倍体或近三倍体作为成人ALL危险分层的一个新的高危因素。(C)2004年，由美国血液病学会提供。
To reveal the relationship between hypodiploidy with 30 to 39 chromosomes and near-triploidy in acute lymphoblastic leukemia (ALL), we studied 24 patients presenting with one of these aneuploidies among 623 adults with ALL registered in the Leucemie Algue Lymphoblastique de l'Adulte (LALA) protocols. The 2 ploidy groups presented a striking similarity of their cytogenetic profiles: chromosomes 2, 3, 4, 7, 13, 15, 16, and 17, significantly monosomic in hypodiploidy 30 to 39, were also frequently disomic in near-triploidy, whereas those retained in pairs in hypo diploidy 30 to 39 were frequently tetrasomic in near-triploidy. DNA content data revealed the simultaneous presence of 2 aneuploid peaks in most tested cases (DNA indexes: 0.72-0.87/1.39-1.89) and a multiple correspondence analysis applied on cytogenetic profiles ascertained their strong relationship. We thus assumed that near-triploidy derives from the duplication of hypodiploidy with 30 to 39 chromosomes and that both aneuploid groups are 2 expressions of the same disease. These 24 patients presented with B-cell phenotype, low leukocytoses (median white blood cell count, 4.2 x 10(9)/L), and poor prognosis (complete remission, 57%; median disease-free-survival, 8 months; median survival, 10.4 months) comparable to that of Ph+ patients treated according to the same protocol. We suggest that hypodiploidy with 30 to 39 chromosomes or near-triploidy should be regarded as a new high-risk factor in the risk stratification of adult ALL protocols. (C) 2004 by The American Society of Hematology.