Prevalence of mild cognitive impairment:: a population-based study in elderly subjects
Prevalence of mild cognitive impairment:: a population-based study in elderly subjects
复制标题
DOI：
10.1034/j.1600-0404.2002.01225.x
复制
发表时间：
2002-09-01
影响因子：
3.5
通讯作者：
Soininen, H
中科院分区：
文献类型：
--
作者：
Hänninen, T;Hallikainen, M;Soininen, H
目的-轻度认知功能障碍（MCI）被认为是正常衰老和痴呆，特别是阿尔茨海默病（AD）之间的一个边界区域。在随访研究中，超过50%的MCI受试者在3-4年内转变为痴呆。然而，MCI的流行病学并不为人所知。本研究旨在确定MCI在老年人群中的患病率。方法：对来自芬兰东部库奥皮奥市的1150名受试者中的806名受试者（60-76岁）进行了评估。采用马约诊所阿尔茨海默病研究中心提出的MCI诊断标准进行神经心理学测试和结构化访谈，包括改良的临床痴呆评分（CDR）。因此，在记忆测试中具有低于年龄适当平均值的超过1.5SD的测试得分和0.5的CDR得分但没有痴呆的受试者被诊断为患有MCI。结果-共有43名受试者（5.3%）符合MCI标准。MCI在年龄较大和受教育程度较低的受试者中更普遍，但男女之间没有差异。CDR似乎是标准中最重要的部分。记忆测试对患病率变量的影响较小。结论：MCI的低患病率表明，在以人群为基础的研究设计中，与老年人群中认知障碍的各种其他标准相比，其标准可能在认知连续体的低端识别出更同质的受试者组。这与后续研究显示MCI组中痴呆症的高概率相一致。因此，可以使用这些诊断标准从老年人群中筛选出痴呆症预防干预试验的可能候选人。
Objectives - Mild cognitive impairment (MCI) has been suggested as a term for a boundary area between normal aging and dementia, especially Alzheimer's disease (AD). In follow-up studies, more than 50% of MCI subjects have been converted to dementia in 3-4 years. However, the epidemiology of MCI is not well known. This study was designed to determine the prevalence of MCI in an elderly population. Methods - A total of 806 subjects (60-76 years of age) from a population-based random sample of 1150 subjects living in the city of Kuopio in eastern Finland were evaluated. Neuropsychological tests and a structured interview including the modified Clinical Dementia Rating (CDR) were used to apply the diagnostic criteria of MCI as proposed by Mayo Clinic Alzheimer's Disease Research Centre. Thus, subjects having a test score more than 1.5 SDs below the age appropriate mean in memory tests and a CDR score of 0.5 but no dementia, were diagnosed as having MCI. Results - A total of 43 subjects, 5.3%, met the MCI criteria. MCI was more prevalent in older and less-educated subjects, but no difference was found between men and women. The CDR appeared to be the most important part of the criteria. The memory tests had less impact on prevalence variables. Conclusions - The low prevalence of MCI indicate that in a population-based study design its criteria may identify a more homogeneous group of subjects at the lower end of the cognitive continuum as contrasted with various other criteria of cognitive impairment in the elderly population. This is compatible with follow-up studies showing a high probability of dementia in the MCI group. Thus, probable candidates for trials of preventive intervention for dementia can be screened from the elderly population using these diagnostic criteria.