Sulfhydryl group in angiotensin converting enzyme inhibitors and superoxide radical formation.
Sulfhydryl group in angiotensin converting enzyme inhibitors and superoxide radical formation.
复制标题
血管紧张素转换酶抑制剂中的巯基和超氧自由基的形成。
DOI：
10.1097/00005344-199011000-00023
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发表时间：
1990
影响因子：
3
通讯作者：
D. Lawson
中科院分区：
文献类型：
--
作者：
J. Mehta;F. Nicolini;D. Lawson
卡托普利分子中SH基团的超氧自由基清除作用被认为是这种血管紧张素转换酶（ACE）抑制剂在心肌损伤动物模型中具有“心脏保护”作用的基础。我们测定了卡托普利，另一种有SH组的ACE抑制剂（SQ 26,703），它的立体异构体没有ACE抑制作用但有SH组（SQ 14,534），另一种没有SH组的ACE抑制剂（依那普利拉）和n -乙酰半胱氨酸对人中性粒细胞和嘌呤-黄嘌呤氧化酶反应产生超氧化物自由基的影响。检测到的化合物中没有一种能降低治疗浓度的超氧自由基；然而，含sh的药物直接降低了铁细胞色素c的分光光度吸光度。因此，具有或不具有ACE抑制作用的含sh药物都不能清除超氧自由基。
The superoxide radical scavenging effects of the SH group in the captopril molecule has been proposed to be the basis of the "cadioprotective" effect of this angiotensin converting enzyme (ACE) inhibitor in animal models of myocardial injury. We determined the effects of captopril, another ACE inhibitor with an SH group (SQ 26,703), its stereoisomer without ACE inhibitory effect but with an SH group (SQ 14,534), another ACE inhibitor without a SH group (enalaprilat), and N-acetylcysteine on superoxide radical generation by human neutrophils and by the purine-xanthine oxidase reaction. None of the compounds examined decreased superoxide radicals in therapeutic concentrations; however, SH-containing agents directly reduced spectrophotometric absorbance of ferricytochrome C. Thus, SH-containing agents with or without ACE inhibitory effects do not scavenge superoxide radicals.