Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study.
Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study.
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DOI：
10.1093/bjs/znac131
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发表时间：
2022-08-16
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影响因子：
--
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中科院分区：
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--
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方法NeST研究方案已发表前10。简言之，这是一项前瞻性多中心队列研究，包括2017年12月1日至2018年11月30日期间在参与单位接受NACT作为乳腺癌主要治疗的连续患者。收集每名参与者的人口统计学资料、多学科小组（MDT）对NACT和术前计划的建议、手术结局和肿瘤学数据。要求MDT前瞻性记录患者在诊断时是否符合保乳条件。pCR定义为不存在残留浸润性疾病，存在或不存在残留原位疾病（ypT 0/ypTis）和阴性腋窝淋巴结（ypN 0）11。进一步的细节中提供的补充material.ResultsA共1283例患者进入NeST研究数据库从39个英国单位;完整的组织病理学和手术结果数据可用于900例患者（916肿瘤）。患者人口统计学和基线肿瘤特征总结见表S1。
MethodsThe NeST study protocol has been published previously 10. Briefly, this was a prospective multicentre cohort study, including consecutive patients in participating units undergoing NACT as primary treatment for breast cancer, between 1 December 2017 and 30 November 2018. Demographics, multidisciplinary team (MDT) recommendations for NACT and preoperative planning, operative outcomes, and oncological data were collected for each participant. MDTs were asked to record prospectively whether patients were eligible for breast conservation at diagnosis. A pCR was defined by the absence of residual invasive disease with or without the presence of residual in situ disease (ypT0/ypTis) with negative axillary nodes (ypN0) 11. Further details are provided in the Supplementary material.ResultsA total of 1283 patients were entered into the NeST study database from 39 UK units; complete histopathological and surgical outcomes data were available for 900 patients (916 tumours). Patient demographics and baseline tumour characteristics are summarized in Table S1.
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