Memory reconsolidation and extinction have distinct temporal and biochemical signatures
Memory reconsolidation and extinction have distinct temporal and biochemical signatures
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DOI：
10.1523/jneurosci.5491-03.2004
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发表时间：
2004-05-19
影响因子：
5.3
通讯作者：
Kida, S
中科院分区：
文献类型：
--
作者：
Suzuki, A;Josselyn, SA;Kida, S
记忆提取不是一种被动的现象。取而代之的是，它触发了一系列过程，要么加强要么改变存储的信息。提取被认为激活了第二个记忆巩固级联(重新巩固)，这需要蛋白质合成。在这里，我们表明记忆再巩固的时间动力学依赖于记忆的强度和年龄，因此较年轻和较弱的记忆比较老和较强的记忆更容易重新巩固。我们还报道了再巩固和消失，这两个由记忆提取触发的相反过程，有不同的生化特征：大麻素受体1或L型电压门控钙通道的药理拮抗作用阻止了消失，但不能阻止再巩固。这些研究证明了提取后记忆加工的动态性质，并代表了分子解剖潜在机制的第一步。
Memory retrieval is not a passive phenomenon. Instead, it triggers a number of processes that either reinforce or alter stored information. Retrieval is thought to activate a second memory consolidation cascade (reconsolidation) that requires protein synthesis. Here, we show that the temporal dynamics of memory reconsolidation are dependent on the strength and age of the memory, such that younger and weaker memories are more easily reconsolidated than older and stronger memories. We also report that reconsolidation and extinction, two opposing processes triggered by memory retrieval, have distinct biochemical signatures: pharmacological antagonism of either cannabinoid receptor 1 or L-type voltage-gated calcium channels blocks extinction but not reconsolidation. These studies demonstrate the dynamic nature of memory processing after retrieval and represent a first step toward a molecular dissection of underlying mechanisms.