Effect of obesity on clinical presentation and response to treatment in asthma
Effect of obesity on clinical presentation and response to treatment in asthma
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DOI：
10.1080/02770900600859123
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发表时间：
2006-09-01
影响因子：
1.9
通讯作者：
Wise, Robert A.
中科院分区：
文献类型：
--
作者：
Dixon, Anne E.;Shade, David M.;Wise, Robert A.
肥胖是被诊断为哮喘的风险因素，但关于肥胖是否是哮喘特有的肺功能异常的风险因素，存在相互矛盾的证据。我们研究了488名受试者，其中47%是肥胖者。患有哮喘的肥胖者和非肥胖者的气流受限和支气管扩张剂反应性相似，但肥胖者睡眠障碍和胃食道反流疾病增加，细胞因子水平更高，在茶碱治疗时有加重的趋势。肥胖和非肥胖哮喘患者的肺功能异常相似，但共病和对药物的反应改变可能会显著影响肥胖者的哮喘控制。
Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.