Interactions of oxidants with vascular signaling systems.
Interactions of oxidants with vascular signaling systems.
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DOI：
10.1161/01.atv.20.6.1430
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发表时间：
2000-06
期刊：
影响因子：
--
通讯作者：
M. Wolin
中科院分区：
文献类型：
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作者：
M. Wolin
单个活性氧（ROS）和NO的氧化产物与血管信号传导机制相互作用的方式，似乎在血管生理和病理生理功能的控制中具有基本的作用。内皮和/或血管平滑肌中ROS产生系统（包括各种NADPH和NADH氧化酶、黄嘌呤氧化酶和NO合酶）的活性由受体活化、氧张力、代谢过程和与血压和流量相关的生理力控制。本文综述了单个活性氧（包括超氧阴离子、过氧化氢和过氧亚硝酸根）的化学性质和代谢传感相互作用如何与细胞调节系统相互作用产生血管反应。这些物种似乎经常通过在个体血红素或巯基氧化还原调节系统（包括鸟苷酸环化酶、环氧合酶、线粒体电子传递和酪氨酸磷酸酶）中产生选择性改变来发挥作用，以通过控制磷脂酶、蛋白激酶、离子通道、收缩蛋白和基因表达的信号传导途径来启动生理反应。
Individual reactive oxygen species (ROS) and oxidation products of NO interact with vascular signaling mechanisms in ways that appear to have fundamental roles in the control of vascular physiological and pathophysiological function. The activities of ROS-producing systems (including various NADPH and NADH oxidases, xanthine oxidase, and NO synthase) in endothelium and/or vascular smooth muscle are controlled by receptor activation, oxygen tension, metabolic processes, and physiological forces associated with blood pressure and flow. This review focuses on how the chemical properties and metabolic sensing interactions of individual ROS (including superoxide anion, hydrogen peroxide, and peroxynitrite) interact with cellular regulatory systems to produce vascular responses. These species appear to often function through producing selective alterations in individual heme or thiol redox-regulated systems (including guanylate cyclase, cyclooxygenase, mitochondrial electron transport, and tyrosine phosphatases) to initiate physiological responses through signaling pathways that control phospholipases, protein kinases, ion channels, contractile proteins, and gene expression.