Sarcomatoid renal cell carcinoma: The chromophobe connection
Sarcomatoid renal cell carcinoma: The chromophobe connection
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DOI：
10.1097/00000478-199710000-00009
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发表时间：
1997-10-01
影响因子：
5.6
通讯作者：
Ali, MA
中科院分区：
文献类型：
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作者：
Akhtar, M;Tulbah, A;Ali, MA
本文对11例肾肉瘤样癌进行了研究，以确定可能与肉瘤样癌转化有关的各亚型肾细胞癌的相对频率。根据所建立的组织学标准，这些肿瘤中的上皮成分被细分为嫌色细胞癌(n=6)、透明细胞癌(n=3)、乳头状癌(n=1)和不确定癌(n=1)。在9例病例中，材料可用于免疫组织化学和DNA倍体研究。所有病例的肉瘤样成分均显示上皮膜抗原细胞角蛋白阳性，表明这些细胞是上皮源性的。除波形蛋白在所有病例中均呈强烈反应外，间充质标记物的染色大多为阴性。使用流式细胞仪和细胞图像分析进行的DNA倍体研究提供了非常相似的结果。在5个嫌色肉瘤样癌中，5个在上皮区显示亚二倍体细胞系，而肉瘤样成分大多显示非整倍体峰。在其余病例中，DNA倍体模式变化较大。这些发现表明，嫌色细胞癌可能是与肉瘤样肾细胞癌相关的最常见的上皮成分。
Eleven cases of sarcomatoid renal cell carcinoma were studied to determine the relative frequency of various subtypes of renal cell carcinoma that may be associated with sarcomatoid trans formation. The epithelial components in these tumors were subcategorized according to established histologic criteria into chromophobe carcinoma (n = 6 cases), clear cell carcinoma (n = 3), papillary carcinoma (n = 1), and indeterminate (n = 1). In nine cases, material was available for immunohistochemical and DNA ploidy studies. The sarcomatoid component in all cases showed positivity for epithelial membrane antigen cytokeratin, indicating an epithelial derivation of these cells. Staining for mesenchymal markers was mostly negative, except for vimentin, which reacted strongly in all cases. DNA ploidy studies using flow cytometry and cell image analysis provided very similar results. Five of five chromophobe sarcomatoid carcinomas showed hypodiploid cell lines in the epithelial areas, whereas the sarcomatoid components mostly showed aneuploid peaks. In the remaining cases, DNA ploidy pattern was more variable. These findings indicate that chromophobe carcinoma may be the most frequent epithelial component associated with sarcomatoid renal cell carcinoma.